مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

188
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

105
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

In vitro activity of recombinant lysostaphin in combination with linezolid, vancomycin and oxacillin against methicillin-resistant Staphylococcus aureus

Pages

  208-212

Keywords

Methicillin resistant Staphylococcus aureus (MRSA) 

Abstract

 Background and Objectives: The antimicrobial combination with synergistic mechanism is recommended to provide broad-spectrum coverage, and prevent the emergence of resistant mutants. In the present study, the Synergistic activity of Lysostaphin with linezolid, oxacillin and vancomycin, against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates was determined. Materials and Methods: Seventy-three MRSA isolates collected from clinical specimens were tested, for in vitro Synergistic activity of Lysostaphin with linezolid, vancomycin and oxacillin, by checkerboard assay. Results: Lysostaphin showed Synergistic activity with linezolid and oxacillin, against all MRSA isolates, tested in the present study. Whereas, only 19. 1% of the isolates showed Synergistic activity with vancomycin and remaining 80. 9% of the MRSA isolates showed additive activity. Conclusion: Lysostaphin causes rapid lysis of S. aureus. Combination therapies that include linezolid and Lysostaphin could be used in life-threatening infections, such as endocarditis to increase the early in vivo activity of the antibiotics, and to prevent the emergence of linezolid resistant mutants. Further, in vivo studies are warranted to confirm our results.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Narasimhaswamy, Nagalakshmi, Bairy, Indira, Shenoy, Gautham, & Bairy, Laxminarayana. (2017). In vitro activity of recombinant lysostaphin in combination with linezolid, vancomycin and oxacillin against methicillin-resistant Staphylococcus aureus. IRANIAN JOURNAL OF MICROBIOLOGY, 9(4), 208-212. SID. https://sid.ir/paper/315516/en

    Vancouver: Copy

    Narasimhaswamy Nagalakshmi, Bairy Indira, Shenoy Gautham, Bairy Laxminarayana. In vitro activity of recombinant lysostaphin in combination with linezolid, vancomycin and oxacillin against methicillin-resistant Staphylococcus aureus. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2017;9(4):208-212. Available from: https://sid.ir/paper/315516/en

    IEEE: Copy

    Nagalakshmi Narasimhaswamy, Indira Bairy, Gautham Shenoy, and Laxminarayana Bairy, “In vitro activity of recombinant lysostaphin in combination with linezolid, vancomycin and oxacillin against methicillin-resistant Staphylococcus aureus,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 9, no. 4, pp. 208–212, 2017, [Online]. Available: https://sid.ir/paper/315516/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button