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1

Information Journal Paper

Title

The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases

Pages

  312-317

Abstract

 Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a Real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13. 9%) were the Beijing lineage and 205 (86. 1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37. 27 ± 18. 3 and 51 ± 21. 2 years, respectively; the difference was statistically significant (P = 0. 001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0. 001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future.

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    APA: Copy

    Erie, Hanifeh, KABOOSI, HAMI, JAVID, NAEME, SHIRZAD ASKI, HESAMADDIN, Taziki, Masoumeh, Babaee Kuchaksaraee, Maya, & GHAEMI, EZZAT ALLAH. (2017). The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases. IRANIAN JOURNAL OF MICROBIOLOGY, 9(6), 312-317. SID. https://sid.ir/paper/315532/en

    Vancouver: Copy

    Erie Hanifeh, KABOOSI HAMI, JAVID NAEME, SHIRZAD ASKI HESAMADDIN, Taziki Masoumeh, Babaee Kuchaksaraee Maya, GHAEMI EZZAT ALLAH. The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2017;9(6):312-317. Available from: https://sid.ir/paper/315532/en

    IEEE: Copy

    Hanifeh Erie, HAMI KABOOSI, NAEME JAVID, HESAMADDIN SHIRZAD ASKI, Masoumeh Taziki, Maya Babaee Kuchaksaraee, and EZZAT ALLAH GHAEMI, “The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 9, no. 6, pp. 312–317, 2017, [Online]. Available: https://sid.ir/paper/315532/en

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