Comparative effects of granulocyte-colony stimulating factor and colistin-alone or in combination on burn wound healing in Acinetobacter baumannii infected mice

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Soleymanzadeh Moghadam Somayeh; Fagheei Aghmiyuni Zeinab; Mazaheri Hassan; Arianpour Nastaran; Danaeifard Mohammad Reza; ROHAM MARYAM; Momeni Mahnoush

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Journal Paper

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Journal: Iranian Journal of Microbiology Year:2018 | Volume:10 | Issue:6 Page(s): 371-377

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Title

Comparative effects of granulocyte-colony stimulating factor and colistin-alone or in combination on burn wound healing in Acinetobacter baumannii infected mice

Author(s)

Keywords

Burn

Granulocyte-colony stimulating factor

Colistin

Acinetobacter baumannii

Wound infection

Abstract

Background and Objectives: Burn wounds are one of the most important health problems all over the world because infection after Burn can delay wound healing. Treating Burn wounds with Granulocyte-colony stimulating factor (G-CSF) is known to improve healing of injured tissue. In addition, Colistin is prescribed as an effective treatment. The aim of this study was to evaluate the effect of G-CSF and Colistin alone or in combination with G-CSF on wound healing of Acinetobacter baumannii (A. baumannii) infected Burns. Materials and Methods: This study was performed between January 2016 and April 2018. Burn wounds were experimentally induced in 36 mice. The wounds were inoculated with A. baumannii. In a 7-day period, Burn wounds in each group were daily treated with subcutaneous injections (0. 1 ml) of saline, G-CSF, Colistin, and G-CSF plus Colistin. After killing the animals, the size of the wound, number of leukocytes in the skin and microbial growth were evaluated. A value of p ≤ 0. 05 was considered statistically significant. Results: Wound healing in the G-CSF plus Colistin group was significantly higher than the control group and the G-CSF group (P = 0. 023 and P = 0. 033, respectively). In G-CSF+Colistin group, the number of leukocytes was higher than the control group considerably (P = 0. 007). On the 7th day of treatment, number of positive bacterial cultures in the Colistin and the G-CSF plus Colistin groups was lower than other groups with a significant difference. Conclusion: Concurrent consumption of G-CSF and antibiotics can control Burn infection and enhance the immune system towards wound healing.

Cites

Histological Survey of the Effect of Granulocyte‑ colony‑ stimulating Factor (G-CSF) on Bacterial Translocation and Wound Healing in Burned Mice

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APA: Copy

Soleymanzadeh Moghadam, Somayeh, Fagheei Aghmiyuni, Zeinab, Mazaheri, Hassan, Arianpour, Nastaran, Danaeifard, Mohammad Reza, ROHAM, MARYAM, & Momeni, Mahnoush. (2018). Comparative effects of granulocyte-colony stimulating factor and colistin-alone or in combination on burn wound healing in Acinetobacter baumannii infected mice. IRANIAN JOURNAL OF MICROBIOLOGY, 10(6), 371-377. SID. https://sid.ir/paper/315541/en

Vancouver: Copy

Soleymanzadeh Moghadam Somayeh, Fagheei Aghmiyuni Zeinab, Mazaheri Hassan, Arianpour Nastaran, Danaeifard Mohammad Reza, ROHAM MARYAM, Momeni Mahnoush. Comparative effects of granulocyte-colony stimulating factor and colistin-alone or in combination on burn wound healing in Acinetobacter baumannii infected mice. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2018;10(6):371-377. Available from: https://sid.ir/paper/315541/en

IEEE: Copy

Somayeh Soleymanzadeh Moghadam, Zeinab Fagheei Aghmiyuni, Hassan Mazaheri, Nastaran Arianpour, Mohammad Reza Danaeifard, MARYAM ROHAM, and Mahnoush Momeni, “Comparative effects of granulocyte-colony stimulating factor and colistin-alone or in combination on burn wound healing in Acinetobacter baumannii infected mice,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 10, no. 6, pp. 371–377, 2018, [Online]. Available: https://sid.ir/paper/315541/en

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