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Information Journal Paper

Title

THE EFFECT OF VITAMIN C ON ENDOTHELIAL FUNCTION OF CHILDREN WITH TYPE 1 DIABETES: AN EXPERIMENTAL STUDY

Pages

  999-1004

Abstract

 Background: Considering the importance of improvement of endothelial function in patients with TYPE 1 DIABETES mellitus (DM) and to prevent its related micro- and macro-vascular complications; in this study, the effect of VITAMIN C administration on improving endothelial function of children with TYPE 1 DIABETES was investigated.Methods: In this analytic-experimental study, children with type 1 DM aged 6-18 years and a group of healthy children enrolled. VITAMIN C (250 mg/daily) administrated for the two studied groups for 1-month. Endothelial function evaluated by flow-mediated dilatation (FMD) and intima-media thickness (IMT) measurement using vascular Doppler ultrasonography, before and after trial.Results: In this study, 18 patients with TYPE 1 DIABETES (DM) and 19 normal children as the control group were studied. After VITAMIN C administration IMT reduced in all studied groups (P<0.05). FMD increased in all studied groups, but it was significant only in the control group (P=0.02 in the control group and P=0.07 in patients with DM). Mean differences of IMT 2 – IMT 1, FMD 2 – FMD 1 and left ventricular (LV) mass 2 – LV mass 1 and blood pressure (BP) were not significantly different in two studied groups (P>0.05). Mean differences of IMT 2 – IMT 1, FMD 2 – FMD 1, LV mass 2 – LV mass 1 and BP were not significantly different in patients with HbA1c £ 7 g/dl and those with HbA1c>7 g/dl and control group (P>0.05).Conclusions: The findings of the current study indicated that VITAMIN C may have a protective effect on endothelial dysfunction, but regarding its effectiveness among the high-risk population such as diabetic patients with and without appropriate glycemic control the study was not sufficiently powered due to its small sample size.

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    APA: Copy

    SABRI, MOHAMMAD REZA, NAJAFI TAVANA, ESFANDIAR, AHMADI, ALIREZA, & HASHEMIPOUR, MAHIN. (2014). THE EFFECT OF VITAMIN C ON ENDOTHELIAL FUNCTION OF CHILDREN WITH TYPE 1 DIABETES: AN EXPERIMENTAL STUDY. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 5(8), 999-1004. SID. https://sid.ir/paper/316071/en

    Vancouver: Copy

    SABRI MOHAMMAD REZA, NAJAFI TAVANA ESFANDIAR, AHMADI ALIREZA, HASHEMIPOUR MAHIN. THE EFFECT OF VITAMIN C ON ENDOTHELIAL FUNCTION OF CHILDREN WITH TYPE 1 DIABETES: AN EXPERIMENTAL STUDY. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2014;5(8):999-1004. Available from: https://sid.ir/paper/316071/en

    IEEE: Copy

    MOHAMMAD REZA SABRI, ESFANDIAR NAJAFI TAVANA, ALIREZA AHMADI, and MAHIN HASHEMIPOUR, “THE EFFECT OF VITAMIN C ON ENDOTHELIAL FUNCTION OF CHILDREN WITH TYPE 1 DIABETES: AN EXPERIMENTAL STUDY,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 5, no. 8, pp. 999–1004, 2014, [Online]. Available: https://sid.ir/paper/316071/en

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