INHIBITORY EFFECT OF GENISTEIN ON PLC/PRF5 HEPATOCELLULAR CARCINOMA CELL LINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NIKBAKHT DASTJERDI MEHDI; KAVOOSI FRAIDOON; VALIANI ALI; ESFANDIARI EBRAHIM; SANAEI MASUME; SOBHANIAN SAEED; GANJALIKHANI HAKEMI MAZDAK; MOBARAKIAN MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Preventive Medicine Year:2015 | Volume:6 | Issue:6 Page(s): 0-0

Download Full-Text

View:

278

Download:

153

Cites:

Information Journal Paper

Title

INHIBITORY EFFECT OF GENISTEIN ON PLC/PRF5 HEPATOCELLULAR CARCINOMA CELL LINE

Author(s)

Keywords

APOPTOSIS

GENISTEIN

HEPATOCELLULAR CARCINOMA

PROLIFERATION

Abstract

Background: Natural compounds including flavonoids like GENISTEIN (GE) are able to inhibit cell PROLIFERATION and induce APOPTOSIS. GE is the main representative of these groups. GE inhibits carcinogenic tumors such as colon, stomach, lung, and pancreas tumors. The aim of the present study was to analyze the apoptotic effect of GE in the HEPATOCELLULAR CARCINOMA (HCC) PLC/PRF5 cell line.Methods: Cells were treated with various doses of GE (1, 5, 10, 25, 50, 75, and 100 mM/L) at different times (24, 48, and 72 h) and the MTT assay was commonly used. Furthermore, cells were treated with single dose of GE (25 mM) at different times and flow cytometry was performed.Results: GE inhibited the growth of liver cancer cells significantly with a time‑ and dose‑dependent manner. The percentage of living cells in GE treatment groups with a concentration of 25 mM at different times were 53, 48 and 47%, respectively (P<0.001). Result of flow cytometry demonstrated that GE at a 25 mM concentration induces APOPTOSIS significantly in a time‑dependent manner. The percentage of apoptotic cells at different times were 44, 56, and 60%, respectively (P<0.001).Conclusions: GE can significantly inhibit the growth of HCC cells and plays a significant role in APOPTOSIS of this cell line.

Cites

No record.

References

No record.

Cite

APA: Copy

NIKBAKHT DASTJERDI, MEHDI, KAVOOSI, FRAIDOON, VALIANI, ALI, ESFANDIARI, EBRAHIM, SANAEI, MASUME, SOBHANIAN, SAEED, GANJALIKHANI HAKEMI, MAZDAK, & MOBARAKIAN, MARYAM. (2015). INHIBITORY EFFECT OF GENISTEIN ON PLC/PRF5 HEPATOCELLULAR CARCINOMA CELL LINE. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 6(6), 0-0. SID. https://sid.ir/paper/316302/en

Vancouver: Copy

NIKBAKHT DASTJERDI MEHDI, KAVOOSI FRAIDOON, VALIANI ALI, ESFANDIARI EBRAHIM, SANAEI MASUME, SOBHANIAN SAEED, GANJALIKHANI HAKEMI MAZDAK, MOBARAKIAN MARYAM. INHIBITORY EFFECT OF GENISTEIN ON PLC/PRF5 HEPATOCELLULAR CARCINOMA CELL LINE. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2015;6(6):0-0. Available from: https://sid.ir/paper/316302/en

IEEE: Copy

MEHDI NIKBAKHT DASTJERDI, FRAIDOON KAVOOSI, ALI VALIANI, EBRAHIM ESFANDIARI, MASUME SANAEI, SAEED SOBHANIAN, MAZDAK GANJALIKHANI HAKEMI, and MARYAM MOBARAKIAN, “INHIBITORY EFFECT OF GENISTEIN ON PLC/PRF5 HEPATOCELLULAR CARCINOMA CELL LINE,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 6, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/316302/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops