ADMINISTRATION OF LACTOBACILLUS CASEI AND BIFIDOBACTERIUM BIFIDUM AMELIORATED HYPERGLYCEMIA, DYSLIPIDEMIA, AND OXIDATIVE STRESS IN DIABETIC RATS

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SHARMA POONAM; BHARDWAJ PRIYANKA; SINGH RAMBIR

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Journal: International Journal of Preventive Medicine Year:2016 | Volume:7 | Issue:- Page(s): 0-0

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Title

ADMINISTRATION OF LACTOBACILLUS CASEI AND BIFIDOBACTERIUM BIFIDUM AMELIORATED HYPERGLYCEMIA, DYSLIPIDEMIA, AND OXIDATIVE STRESS IN DIABETIC RATS

Author(s)

SHARMA POONAM | BHARDWAJ PRIYANKA | SINGH RAMBIR | Issue Writer Certificate

Keywords

ANTIHYPERGLYCEMIC

ANTIOXIDANT

BIFIDOBACTERIUM BIFIDUM

DYSLIPIDEMIA

LACTOBACILLUS CASEI

Abstract

Background: The present work was planned to evaluate the ANTIHYPERGLYCEMIC, lipid‑lowering, and ANTIOXIDANT effect of LACTOBACILLUS CASEI and BIFIDOBACTERIUM BIFIDUM in streptozotocin (STZ) ‑induced diabetic rats.Methods: Single daily dose of 1 × 107 cfu/ml of L. casei and B. bifidum alone and in combination of both was given to Wistar rats orally by gavaging for 28 days. Glucose tolerance test, fasting blood glucose (FBG), lipid profile, and glycosylated hemoglobin (HbA1c) were measured from blood.Glycogen from thigh muscles and liver and oxidative stress parameters from pancreas were analyzed.Results: Administration of L. casei and B. bifidum alone and in combination of both to diabetic rats decreased serum FBG (60.47%, 55.89%, and 56.49%, respectively), HbA1c (28.11%, 28.61%, and 28.28%), total cholesterol (171.69%, 136.47%, and 173.58%), triglycerides (9.935%, 8.58%, and 7.91%), low‑density lipoproteins (53.27%, 53.35%, and 52.91%) and very low‑density lipoproteins (10%, 8.58%, and 11.15%, respectively) and increased high‑density lipoproteins (13.73%, 15.47%, and 15.47%), and insulin (19.50%, 25.80%, and 29.47%, respectively). The treatment also resulted in increase in muscle (171.69%, 136.47%, and 173.58%) and liver (25.82%, 6.63%, and 4.02%) glycogen level. The ANTIOXIDANT indexes in pancreas of diabetic rats returned to normal level with reduction in lipid peroxidation (30.89%, 46.46%, and 65.36%) and elevation in reduced glutathione (104.5%, 161.34%, and 179.04%), superoxide dismutase (38.65%, 44.32%, and 53.35%), catalase (13.08%, 27%, and 31.52%), glutathione peroxidase (55.56%, 72.23%, and 97.23%), glutathione reductase (49.27%, 88.40%, and 110.86%), and glutathione‑S‑transferase (140%, 220%, and 246.6%, respectively) on treatment with L. casei, B. bifidum, and combination treatment.Conclusions: Administration of L. casei and B. bifidum alone and in combination of both ameliorated hyperglycemia, DYSLIPIDEMIA, and oxidative stress in STZ‑induced diabetic Wistar rats.

Cites

The effects of the Lactobacillus acidophilus ATCC 4356 on the oxidative stress of reproductive system in diabetic male rats

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APA: Copy

SHARMA, POONAM, BHARDWAJ, PRIYANKA, & SINGH, RAMBIR. (2016). ADMINISTRATION OF LACTOBACILLUS CASEI AND BIFIDOBACTERIUM BIFIDUM AMELIORATED HYPERGLYCEMIA, DYSLIPIDEMIA, AND OXIDATIVE STRESS IN DIABETIC RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 7(-), 0-0. SID. https://sid.ir/paper/316393/en

Vancouver: Copy

SHARMA POONAM, BHARDWAJ PRIYANKA, SINGH RAMBIR. ADMINISTRATION OF LACTOBACILLUS CASEI AND BIFIDOBACTERIUM BIFIDUM AMELIORATED HYPERGLYCEMIA, DYSLIPIDEMIA, AND OXIDATIVE STRESS IN DIABETIC RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2016;7(-):0-0. Available from: https://sid.ir/paper/316393/en

IEEE: Copy

POONAM SHARMA, PRIYANKA BHARDWAJ, and RAMBIR SINGH, “ADMINISTRATION OF LACTOBACILLUS CASEI AND BIFIDOBACTERIUM BIFIDUM AMELIORATED HYPERGLYCEMIA, DYSLIPIDEMIA, AND OXIDATIVE STRESS IN DIABETIC RATS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 7, no. -, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/316393/en

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