EFFECTS OF ADMINISTERING PROPHYLACTIC ACETAMINOPHEN ON SHORT‑TERM COMPLICATIONS OF VACCINATION IN 6‑MONTH‑OLD INFANTS

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KARAMBIN MOHAMMAD MEHDI; HEIDARZADEH ABTIN; SHARGHY ROSE; DALILI SETILA; HASHEMIAN HOUMAN

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Journal: International Journal of Preventive Medicine Year:2015 | Volume:6 | Issue:- Page(s): 0-0

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Title

EFFECTS OF ADMINISTERING PROPHYLACTIC ACETAMINOPHEN ON SHORT‑TERM COMPLICATIONS OF VACCINATION IN 6‑MONTH‑OLD INFANTS

Author(s)

Keywords

ACETAMINOPHEN

CHILD

VACCINATION

Abstract

Background: We aimed to assess the effects of administering prophylactic ACETAMINOPHEN onshort‑term complications of VACCINATION in 6‑month‑old infants admitted to a private pediatric clinicin Rasht (Iran) during 2002–2013.Methods: This quasi‑experimental study was conducted on 696, infants aged 6‑month‑oldadmitted to a pediatric clinic in Rasht before VACCINATION during 2002–2013. Overall, 31 infantswere excluded during the course of the study. While prophylactic ACETAMINOPHEN was administeredin 322 participants (intervention group), 343 infants (control group) received ACETAMINOPHENafter VACCINATION. Data were collected by a checklist including complications such as fever, drowsiness, anorexia, seizure, long and excessive crying, mood change, pain, and wound atthe site of injection, abscess, induration, limb swelling, and erythema. The time of occurrenceof each complication was also recorded. Data were analyzed by Chi‑square test in SPSS 16.0.P<0.05 was considered significant.Results: Six hundred sixty‑five participants (49.6% boy) were assessed in this study. Theintervention and control groups had no significant difference in terms of sex distribution (P=0.53).Short‑term complications occurred in 45% of the infants. The most common complications wereerythema (24.4%), induration (19.9%), and low‑grade fever (16.1%). There was a significantrelation between administering prophylactic ACETAMINOPHEN and the incidence of low‑grade fever(P=0.01), induration (P=0.01), and anorexia (P=0.03).Conclusions: Our findings indicated the efficacy of prophylactic ACETAMINOPHEN in reducingpostvaccination complications in a population of Iranian infants. According to our findings, furtherresearch is required to determine the preferred dose and time of administering ACETAMINOPHEN.

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APA: Copy

KARAMBIN, MOHAMMAD MEHDI, HEIDARZADEH, ABTIN, SHARGHY, ROSE, DALILI, SETILA, & HASHEMIAN, HOUMAN. (2015). EFFECTS OF ADMINISTERING PROPHYLACTIC ACETAMINOPHEN ON SHORT?TERM COMPLICATIONS OF VACCINATION IN 6?MONTH?OLD INFANTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 6(-), 0-0. SID. https://sid.ir/paper/316401/en

Vancouver: Copy

KARAMBIN MOHAMMAD MEHDI, HEIDARZADEH ABTIN, SHARGHY ROSE, DALILI SETILA, HASHEMIAN HOUMAN. EFFECTS OF ADMINISTERING PROPHYLACTIC ACETAMINOPHEN ON SHORT?TERM COMPLICATIONS OF VACCINATION IN 6?MONTH?OLD INFANTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2015;6(-):0-0. Available from: https://sid.ir/paper/316401/en

IEEE: Copy

MOHAMMAD MEHDI KARAMBIN, ABTIN HEIDARZADEH, ROSE SHARGHY, SETILA DALILI, and HOUMAN HASHEMIAN, “EFFECTS OF ADMINISTERING PROPHYLACTIC ACETAMINOPHEN ON SHORT?TERM COMPLICATIONS OF VACCINATION IN 6?MONTH?OLD INFANTS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 6, no. -, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/316401/en

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