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Information Journal Paper

Title

EFFECT OF FINGOLIMOD ON PLATELET COUNT AMONG MULTIPLE SCLEROSIS PATIENTS

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  0-0

Abstract

 Background: While many studies have previously focused on FINGOLIMOD’s effect on immunecells, the effect it has on circulating and local central nervous system PLATELETs (Plts) has not yetbeen investigated. This study will elucidate what effects FINGOLIMOD treatment has on multiplesclerosis (MS) patients’ plasma Plt levels. In addition, it will propose possible reasoning for theseeffects and suggest further investigation into this topic.Methods: This quasi‑experimental study used patients from the Isfahan MULTIPLE SCLEROSIS Societyto produce a subject pool of 80 patients, including 14 patients who ceased FINGOLIMOD use due tocomplications. The patients had their blood analyzed to determine Plt levels both 1‑month priorto FINGOLIMOD treatment and 1‑month after FINGOLIMOD treatment had been started.Results: The mean level of Plts before initiation of FINGOLIMOD therapy (Plt1) among these MSpatients was 256.53 ± 66.26. After 1‑month of FINGOLIMOD treatment, the Plt level yielded anaverage of 229.96 ± 49.67 (Plt2). This number is significantly lower than the average Plt countbefore treatment (P<0.01).Conclusions: MS patients taking oral FINGOLIMOD treatment may be at risk for side‑effects causedby low Plt levels. This may not be a factor for patients with higher or normal Plt levels. However, a patient with naturally low Plt levels may experience a drop below the normal level and be atrisk for excessive bleeding. In addition to these possible harmful side‑effects, the decreased Pltpopulation may pose positive effects for MS patients.

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    APA: Copy

    FARROKHI, MEHRDAD, Amani Beni, Ali, ETEMADIFAR, MASOUD, REZAEI, ALI, RIVARD, LEAH, RAFIEE ZADEH, ARYAN, Sedaghat, Nahid, & Ghadimi, Milad. (2015). EFFECT OF FINGOLIMOD ON PLATELET COUNT AMONG MULTIPLE SCLEROSIS PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 6(-), 0-0. SID. https://sid.ir/paper/316402/en

    Vancouver: Copy

    FARROKHI MEHRDAD, Amani Beni Ali, ETEMADIFAR MASOUD, REZAEI ALI, RIVARD LEAH, RAFIEE ZADEH ARYAN, Sedaghat Nahid, Ghadimi Milad. EFFECT OF FINGOLIMOD ON PLATELET COUNT AMONG MULTIPLE SCLEROSIS PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2015;6(-):0-0. Available from: https://sid.ir/paper/316402/en

    IEEE: Copy

    MEHRDAD FARROKHI, Ali Amani Beni, MASOUD ETEMADIFAR, ALI REZAEI, LEAH RIVARD, ARYAN RAFIEE ZADEH, Nahid Sedaghat, and Milad Ghadimi, “EFFECT OF FINGOLIMOD ON PLATELET COUNT AMONG MULTIPLE SCLEROSIS PATIENTS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 6, no. -, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/316402/en

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