مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CYCLOPHOSPHAMIDE‑INDUCED HEPATOTOXICITY IN WISTAR RATS: THE MODULATORY ROLE OF GALLIC ACID AS A HEPATOPROTECTIVE AND CHEMOPREVENTIVE PHYTOCHEMICAL

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Abstract

 Background: GALLIC ACID (GA) is an endogenous plant phenol known to have ANTIOXIDANT, free radical scavenging ability, anti‑inflammatory, anti‑cancer, and anti‑fungal properties. The aim of this study was to assess the protective effect of GA on CYCLOPHOSPHAMIDE (CPA) ‑induced HEPATOTOXICITY in male Wistar rats.Methods: Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally.Results: CPA induced hepatic damage as indicated by significant elevation (P<0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic OXIDATIVE STRESS as indicated by significant elevation (P<0.05) in malondialdehyde content, hydrogen peroxide (H2O2) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA‑treated group. GA enhanced the ANTIOXIDANT defense system as indicated by significant elevation (P<0.05) in GSH level, catalase activity, and GSH‑S‑transferase activity.Conclusions: Taken together, the result of this present study shows that GA has a protective effect on CPA‑induced HEPATOTOXICITY.

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    APA: Copy

    OYAGBEMI, ADEMOLA ADETOKUNBO, OMOBOWALE, OLUTAYO TEMIDAYO, ASENUGA, EBUNOLUWA RACHAEL, AKINLEYE, AKINRINDE STEPHEN, OGUNSANWO, RACHAEL OMOLOLA, & SABA, ADEBOWALE BERNARD. (2016). CYCLOPHOSPHAMIDE?INDUCED HEPATOTOXICITY IN WISTAR RATS: THE MODULATORY ROLE OF GALLIC ACID AS A HEPATOPROTECTIVE AND CHEMOPREVENTIVE PHYTOCHEMICAL. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 7(-), 0-0. SID. https://sid.ir/paper/316488/en

    Vancouver: Copy

    OYAGBEMI ADEMOLA ADETOKUNBO, OMOBOWALE OLUTAYO TEMIDAYO, ASENUGA EBUNOLUWA RACHAEL, AKINLEYE AKINRINDE STEPHEN, OGUNSANWO RACHAEL OMOLOLA, SABA ADEBOWALE BERNARD. CYCLOPHOSPHAMIDE?INDUCED HEPATOTOXICITY IN WISTAR RATS: THE MODULATORY ROLE OF GALLIC ACID AS A HEPATOPROTECTIVE AND CHEMOPREVENTIVE PHYTOCHEMICAL. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2016;7(-):0-0. Available from: https://sid.ir/paper/316488/en

    IEEE: Copy

    ADEMOLA ADETOKUNBO OYAGBEMI, OLUTAYO TEMIDAYO OMOBOWALE, EBUNOLUWA RACHAEL ASENUGA, AKINRINDE STEPHEN AKINLEYE, RACHAEL OMOLOLA OGUNSANWO, and ADEBOWALE BERNARD SABA, “CYCLOPHOSPHAMIDE?INDUCED HEPATOTOXICITY IN WISTAR RATS: THE MODULATORY ROLE OF GALLIC ACID AS A HEPATOPROTECTIVE AND CHEMOPREVENTIVE PHYTOCHEMICAL,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 7, no. -, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/316488/en

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