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Title

CLINICAL EFFICACY AND SAFETY OF METHOTREXATE VERSUS HYDROXYCHLOROQUINE IN PREVENTING LICHEN PLANOPILARIS PROGRESS: A RANDOMIZED CLINICAL TRIAL

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Abstract

 Background: LICHEN PLANOPILARIS is an inflammatory cicatricial alopecia, and its management is a challenge for dermatologists. We aimed to compare the efficacy of METHOTREXATE and HYDROXYCHLOROQUINE on refractory LICHEN PLANOPILARIS.Methods: In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg METHOTREXATE/week or 200 mg HYDROXYCHLOROQUINE twice a day for 6 months. Side effects, symptoms/signs, and laboratory tests were assessed periodically. LICHEN PLANOPILARIS Activity Index (LPPAI) was measured before intervention and at 2, 4, and 6 months after. The changes from baseline to the end of the study were analyzed within each group and between the two groups by per‑protocol and intention‑to‑treat analysis.Results: After 2 months, mean (standard deviation [SD]) decrease in LPPAI in METHOTREXATE group was significantly more than that in HYDROXYCHLOROQUINE group (1.68 [1.24] vs.0.8 [0.71], respectively, P=0.047). Furthermore, after 6 months, mean (SD) decrease in LPPAI in METHOTREXATE group was significantly higher than that in HYDROXYCHLOROQUINE group (3.3 [2.09] vs.1.51 [0.91], respectively, P=0.01). The following symptoms/signs showed significant improvements in frequency and/or severity in METHOTREXATE group after intervention: pruritus (P=0.007), erythema (P=0.01), perifollicular erythema (P=0.01), perifollicular scaling (P=0.08), spreading (P=0.001), and follicular keratosis (P=0.04). In HYDROXYCHLOROQUINE group, only erythema (P=0.004) showed significant improvement.Conclusions: METHOTREXATE was more effective than HYDROXYCHLOROQUINE in treating refractory LICHEN PLANOPILARIS.

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    APA: Copy

    FATEMI NAEINI, FARAHNAZ, SABER, MINA, ASILIAN, ALI, & HOSSEINI, SEYED MOHSEN. (2017). CLINICAL EFFICACY AND SAFETY OF METHOTREXATE VERSUS HYDROXYCHLOROQUINE IN PREVENTING LICHEN PLANOPILARIS PROGRESS: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 8(-), 0-0. SID. https://sid.ir/paper/316537/en

    Vancouver: Copy

    FATEMI NAEINI FARAHNAZ, SABER MINA, ASILIAN ALI, HOSSEINI SEYED MOHSEN. CLINICAL EFFICACY AND SAFETY OF METHOTREXATE VERSUS HYDROXYCHLOROQUINE IN PREVENTING LICHEN PLANOPILARIS PROGRESS: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2017;8(-):0-0. Available from: https://sid.ir/paper/316537/en

    IEEE: Copy

    FARAHNAZ FATEMI NAEINI, MINA SABER, ALI ASILIAN, and SEYED MOHSEN HOSSEINI, “CLINICAL EFFICACY AND SAFETY OF METHOTREXATE VERSUS HYDROXYCHLOROQUINE IN PREVENTING LICHEN PLANOPILARIS PROGRESS: A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 8, no. -, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/316537/en

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