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Title

ASSOCIATION OF SERUM 25‑HYDROXYVITAMIN D LEVELS AND LIVER ENZYMES IN A NATIONALLY REPRESENTATIVE SAMPLE OF IRANIAN ADOLESCENTS: THE CHILDHOOD AND ADOLESCENCE SURVEILLANCE AND PREVENTION OF ADULT NONCOMMUNICABLE DISEASE STUDY

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Abstract

 Background: Hypovitaminosis D is highly prevalent and has several adverse health effects. This study aims to assess the relationship of serum concentrations of 25‑hydroxyvitamin D (25 [OH] D) and liver enzymes in ADOLESCENTs.Methods: This population‑based cross‑sectional survey was conducted among a nationally representative multistage sample of 1095 ADOLESCENTs (52% boys), aged 10–18 years, living in different provinces of Iran. Serum 25 (OH) D concentration<30 ng/ mL was considered as hypovitaminosis D, and liver enzymes (alanine aminotransaminase [ALT] and aspartate aminotransaminase [AST]) of>40 U/L was considered as high level. To determine the association between serum 25 (OH) D categories and elevated levels of liver enzymes, multiple regression models and linear regression analysis were applied, after adjustment for potential confounders. Odds ratios (95% confidence interval) of serum 25 (OH) D and elevated liver enzymes were assessed by logistic regression analysis.Results: Higher rates of VITAMIN D deficiency were documented among individuals with increased levels of liver enzymes. Compared to boys, median of 25 (OH) D was lower in girls with elevated levels of LIVER FUNCTION TESTS (12.75 vs.25.60 ng/mL for ALT and 13 vs.14.10 ng/mL for AST), with marginally significant gender differences regarding AST.Conclusions: We found a relatively high frequency of hypovitaminosis D among ADOLESCENTs with abnormal liver function. Further prospective studies are needed to examine these associations from early life.

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    APA: Copy

    BAHREYNIAN, MARYAM, QORBANI, MOSTAFA, MOTLAGH, MOHAMMAD ESMAEIL, HESHMAT, RAMIN, KHADEMIAN, MAJID, & KELISHADI, ROYA. (2018). ASSOCIATION OF SERUM 25?HYDROXYVITAMIN D LEVELS AND LIVER ENZYMES IN A NATIONALLY REPRESENTATIVE SAMPLE OF IRANIAN ADOLESCENTS: THE CHILDHOOD AND ADOLESCENCE SURVEILLANCE AND PREVENTION OF ADULT NONCOMMUNICABLE DISEASE STUDY. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 9(-), 0-0. SID. https://sid.ir/paper/316581/en

    Vancouver: Copy

    BAHREYNIAN MARYAM, QORBANI MOSTAFA, MOTLAGH MOHAMMAD ESMAEIL, HESHMAT RAMIN, KHADEMIAN MAJID, KELISHADI ROYA. ASSOCIATION OF SERUM 25?HYDROXYVITAMIN D LEVELS AND LIVER ENZYMES IN A NATIONALLY REPRESENTATIVE SAMPLE OF IRANIAN ADOLESCENTS: THE CHILDHOOD AND ADOLESCENCE SURVEILLANCE AND PREVENTION OF ADULT NONCOMMUNICABLE DISEASE STUDY. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2018;9(-):0-0. Available from: https://sid.ir/paper/316581/en

    IEEE: Copy

    MARYAM BAHREYNIAN, MOSTAFA QORBANI, MOHAMMAD ESMAEIL MOTLAGH, RAMIN HESHMAT, MAJID KHADEMIAN, and ROYA KELISHADI, “ASSOCIATION OF SERUM 25?HYDROXYVITAMIN D LEVELS AND LIVER ENZYMES IN A NATIONALLY REPRESENTATIVE SAMPLE OF IRANIAN ADOLESCENTS: THE CHILDHOOD AND ADOLESCENCE SURVEILLANCE AND PREVENTION OF ADULT NONCOMMUNICABLE DISEASE STUDY,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 9, no. -, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/316581/en

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