IN VITRO INHIBITORY EFFECTS OF THE HERBAL-MARINE COMPOUND HESA-A AGAINST REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1

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VAHABPOUR ROUHOLLAH; SADAT SEYED MEHDI; ZABIHOLLAHI REZVAN; AHMADI AMR ELAH; KEYVANI HOSSEIN; AMINI SAFIEH; SIADAT SEYED DAVAR; AGHASADEGHI MOHAMMAD REZA

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Journal: Jundishapur Journal of Microbiology Year:2012 | Volume:5 | Issue:1 (S.N. 15) Page(s): 315-319

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Title

IN VITRO INHIBITORY EFFECTS OF THE HERBAL-MARINE COMPOUND HESA-A AGAINST REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1

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Keywords

HUMAN IMMUNODEFICIENCY VIRUS

HESA-A

HERBAL MEDICINE

ANTIVIRAL AGENTS

Abstract

Background: For more than 2 decades, HUMAN IMMUNODEFICIENCY VIRUS (HIV) infection has been known to cause significant morbidity and mortality. Difficulties in treating HIV-infected patients include adverse effects and drug resistance and continue to limit the use of conventional anti-retroviral therapies.Objectives: To find new anti-retroviral drugs from natural sources, we investigated the inhibitory effects and mechanism of action of HESA-A, a natural biological compound of herbal-marine origin, against HIV-1 replicationin vitro.Materials and Methods: In this study, we used a single-cycle replicable HIV-1 system in which co-transfection of human embryonic kidney (HEK) -293T cells with pmzNL4-3, psPAX2, and pM2G.2 plasmids was performed. Cytotoxicity and cytopathic protection assays were performed using the 2, 3-bis- (2-methoxy-4-nitro-5-sulfophenyl) - (2H) -tetrazolium-5-carboxanilide method. Inhibition of p24 antigen production was analyzed, and time-of-drug-addition assay was conducted using quantitative enzyme-linked immunosorbent assay (ELISA).Results: HESA-A inhibited HIV-1-induced cytopathic effect in MT2 and HEK293T cells, and the selectivity index values were 13.3 and 8, respectively. We performed quantitative p24 ELISA and added varying concentrations of HESA-A in cell culture supernatants at different times; we observed that HESA-A preserved its ability to inhibit viral replication even at 12 h post-infection.Conclusions: These results suggest that HESA-A has potent anti-HIV activity, and its mechanism of action likely involves interference during the late stages of viral replication, such as virus maturation.

Cites

THE EFFECTIVENESS OF HESA-A SUPPLEMENT COMBINED WITH ATORVASTATIN ON NONALCOHOLIC FATTY LIVER IN RATS

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APA: Copy

VAHABPOUR, ROUHOLLAH, SADAT, SEYED MEHDI, ZABIHOLLAHI, REZVAN, AHMADI, AMR ELAH, KEYVANI, HOSSEIN, AMINI, SAFIEH, SIADAT, SEYED DAVAR, & AGHASADEGHI, MOHAMMAD REZA. (2012). IN VITRO INHIBITORY EFFECTS OF THE HERBAL-MARINE COMPOUND HESA-A AGAINST REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 5(1 (S.N. 15)), 315-319. SID. https://sid.ir/paper/317254/en

Vancouver: Copy

VAHABPOUR ROUHOLLAH, SADAT SEYED MEHDI, ZABIHOLLAHI REZVAN, AHMADI AMR ELAH, KEYVANI HOSSEIN, AMINI SAFIEH, SIADAT SEYED DAVAR, AGHASADEGHI MOHAMMAD REZA. IN VITRO INHIBITORY EFFECTS OF THE HERBAL-MARINE COMPOUND HESA-A AGAINST REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2012;5(1 (S.N. 15)):315-319. Available from: https://sid.ir/paper/317254/en

IEEE: Copy

ROUHOLLAH VAHABPOUR, SEYED MEHDI SADAT, REZVAN ZABIHOLLAHI, AMR ELAH AHMADI, HOSSEIN KEYVANI, SAFIEH AMINI, SEYED DAVAR SIADAT, and MOHAMMAD REZA AGHASADEGHI, “IN VITRO INHIBITORY EFFECTS OF THE HERBAL-MARINE COMPOUND HESA-A AGAINST REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 5, no. 1 (S.N. 15), pp. 315–319, 2012, [Online]. Available: https://sid.ir/paper/317254/en

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