INTENSITY OF HLA-A2 EXPRESSION SIGNIFICANTLY DECREASED IN OCCULT HEPATITIS B INFECTION

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ASKARI AZAM; HASSANSHAHI GHOLAMHOSSEIN; GHALEBI SEYED RAZI; JAFARZADEH ABDOLLAH; MOHIT MARYAM; HAJGHANI MASOMEH; KAZEMI ARABABADI MOHAMMAD

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Journal: Jundishapur Journal of Microbiology Year:2014 | Volume:7 | Issue:6 Page(s): 1-4

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Title

INTENSITY OF HLA-A2 EXPRESSION SIGNIFICANTLY DECREASED IN OCCULT HEPATITIS B INFECTION

Author(s)

Keywords

OCCULT

HEPATITIS B

INFECTION

HLA-A2

DNA

Abstract

Background: OCCULT HEPATITIS B infected (OBI) patients cannot eradicate HEPATITIS B virus (HBV) -DNA from their liver and peripheral blood, completely.Objectives: The main aim of this study was to investigate the rate of HLA-A2 expression on peripheral blood mononuclear cells (PBMCs) of patients with OBI.Materials and Methods: In this experimental study, intensity of HLA-A2 was measured on the PBMCs of 57 OBI patients and 100 HBsAg-/anti-HBc+/HBV-DNA samples were enrolled as controls; measurements were performed using the flow cytometry technique.Results: Flow cytometric analysis indicated that 19 (33.3%) OBI patients and 28 (28%) controls expressed HLA-A2 antigen on their PBMCs. There was no significant difference between the two groups regarding the rate of individuals expressing HLA-A2 antigen. Statistical analyses showed that the intensity of HLA-A2 expression significantly decreased in OBI patients (3.58±0.1) in comparison to healthy controls (4.21±0.25; P<0.001).Conclusions: According to these results it can be concluded that decreased intensity of HLA-A2 on the PBMCs of OBI patients may lead to resistance of HBV in the patients.

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APA: Copy

ASKARI, AZAM, HASSANSHAHI, GHOLAMHOSSEIN, GHALEBI, SEYED RAZI, JAFARZADEH, ABDOLLAH, MOHIT, MARYAM, HAJGHANI, MASOMEH, & KAZEMI ARABABADI, MOHAMMAD. (2014). INTENSITY OF HLA-A2 EXPRESSION SIGNIFICANTLY DECREASED IN OCCULT HEPATITIS B INFECTION. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(6), 1-4. SID. https://sid.ir/paper/317368/en

Vancouver: Copy

ASKARI AZAM, HASSANSHAHI GHOLAMHOSSEIN, GHALEBI SEYED RAZI, JAFARZADEH ABDOLLAH, MOHIT MARYAM, HAJGHANI MASOMEH, KAZEMI ARABABADI MOHAMMAD. INTENSITY OF HLA-A2 EXPRESSION SIGNIFICANTLY DECREASED IN OCCULT HEPATITIS B INFECTION. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2014;7(6):1-4. Available from: https://sid.ir/paper/317368/en

IEEE: Copy

AZAM ASKARI, GHOLAMHOSSEIN HASSANSHAHI, SEYED RAZI GHALEBI, ABDOLLAH JAFARZADEH, MARYAM MOHIT, MASOMEH HAJGHANI, and MOHAMMAD KAZEMI ARABABADI, “INTENSITY OF HLA-A2 EXPRESSION SIGNIFICANTLY DECREASED IN OCCULT HEPATITIS B INFECTION,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 7, no. 6, pp. 1–4, 2014, [Online]. Available: https://sid.ir/paper/317368/en

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