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Title

INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN

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Abstract

 Background: CUTANEOUS LEISHMANIASIS is a health problem in the world. Lesions should be treated on cosmetically or functionally important sites, such as the face and hands. CANTHARIDIN is a terpenoid compound produced naturally by beetles of Meloidae and Oedemeridae families.Objectives: The current study aimed to investigate the effect of CANTHARIDIN on CUTANEOUS LEISHMANIASIS (CL) lesions and IFN-ϒ and IL-4 patterns in infected BALB/c MICE.Materials and Methods: Infected BALB/c MICE were divided into five groups as: untreated (control group), eucerin-treated and 0.05%, 0.1% and 0.5% CANTHARIDIN-treated. Lesions diameter was measured by Vernier caliper every three days for four weeks. Cytokines levels were measured by enzyme-linked immunosorbent assay (ELISA) using U-CyTech kit.Results: The results indicated that treatment with CANTHARIDIN exacerbates lesions compared with the controls, except for 0.05% CANTHARIDIN dose that restrained lesion growth significantly. Interferon gamma level in CANTHARIDIN-treated groups was significantly less than that of the control group. But interlukin-4 level was similar among the groups.Conclusions: The current study results indicated that high doses of CANTHARIDIN exacerbates LEISHMANIASIS lesion, but low dose of CANTHARIDIN inhibits lesion growth.

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    APA: Copy

    MAROUFI, YAHYA, GHAFFARIFAR, FATEMEH, DALIMI, ABDOLHOSSEIN, & SHARIFI, ZOHREH. (2014). INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(6), 0-0. SID. https://sid.ir/paper/317382/en

    Vancouver: Copy

    MAROUFI YAHYA, GHAFFARIFAR FATEMEH, DALIMI ABDOLHOSSEIN, SHARIFI ZOHREH. INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2014;7(6):0-0. Available from: https://sid.ir/paper/317382/en

    IEEE: Copy

    YAHYA MAROUFI, FATEMEH GHAFFARIFAR, ABDOLHOSSEIN DALIMI, and ZOHREH SHARIFI, “INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 7, no. 6, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/317382/en

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