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Information Journal Paper

Title

POST-VACCINATION DISSEMINATED BACILLUS CALMETTE GUERIN INFECTION AMONG CHILDREN IN SOUTHERN IRAN

Pages

  1-7

Abstract

 Background: Disseminated bacillus calmette guerin (BCG) infection is a rare but life threatening complication of BCG vaccination. It has been mainly seen in severe immune deficiency. A precise and rapid diagnosis is crucial for prompt initiation of an aggressive anti-mycobacterial treatment. POLYMERASE CHAIN REACTION (PCR) is directly applicable to smear-positive clinical specimens, proven to be a rapid and specific diagnostic test.Objectives: The aim of this study was to investigate disseminated BCG infection among 34 children in southern IRAN, mainly confirmed by PCR.Patients and Methods: We included all the patients hospitalized with disseminated BCG infection at a referral teaching hospital in southern IRAN between years 1990 and 2007. The clinical and laboratory data including the immunological workups were obtained through a review of the medical files. We recalled all pathology samples from pathology specimen banks and used an in-house PCR specific for Mycobacterium bovis BCG substrain to confirm the diagnosis.Results: From the total of 34 children hospitalized with disseminated BCG infection, 21 were categorized as definite and 13 probable. Thirty-one patients (91%) were under two years of age and 41% were male. The most common clinical findings were fever in 31 (91.2%), axillary’s lymphadenopathy in 26 (76.5%), hepatosplenomegaly in 25 (73.5%), stunted growth in 21 (61.8%), and distant lymphadenopathy in 16 (47.1%). POLYMERASE CHAIN REACTION positivity rate was 100% (9 of 9) in bone marrow smear slides and 84.2% (16 of 19) for formalin-fixed and paraffin-embedded tissue specimens. Immunodeficiency state was detected in 50% and the overall mortality rate was 58.8% (20 of 34).Conclusions: Disseminated BCG infection should be considered in the differential diagnosis of infants and young children with fever, hepatosplenomegaly, lymphadenopathy, and history of BCG vaccination. The PCR method has a high positivity rate and can serve as a useful tool for the rapid and specific identification of M. bovis BCG substrain infection.

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    APA: Copy

    AELAMI, MOHAMMAD HASAN, ALBORZI, ABDOLVAHAB, POULADFAR, GHOLAMREZA, GERAMIZADEH, BITA, POURABBAS, BAHMAN, & MARDANEH, JALAL. (2015). POST-VACCINATION DISSEMINATED BACILLUS CALMETTE GUERIN INFECTION AMONG CHILDREN IN SOUTHERN IRAN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(11), 1-7. SID. https://sid.ir/paper/317432/en

    Vancouver: Copy

    AELAMI MOHAMMAD HASAN, ALBORZI ABDOLVAHAB, POULADFAR GHOLAMREZA, GERAMIZADEH BITA, POURABBAS BAHMAN, MARDANEH JALAL. POST-VACCINATION DISSEMINATED BACILLUS CALMETTE GUERIN INFECTION AMONG CHILDREN IN SOUTHERN IRAN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(11):1-7. Available from: https://sid.ir/paper/317432/en

    IEEE: Copy

    MOHAMMAD HASAN AELAMI, ABDOLVAHAB ALBORZI, GHOLAMREZA POULADFAR, BITA GERAMIZADEH, BAHMAN POURABBAS, and JALAL MARDANEH, “POST-VACCINATION DISSEMINATED BACILLUS CALMETTE GUERIN INFECTION AMONG CHILDREN IN SOUTHERN IRAN,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 11, pp. 1–7, 2015, [Online]. Available: https://sid.ir/paper/317432/en

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