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Information Journal Paper

Title

UTILIZATION OF HUMAN PAPILLOMAVIRUS DNA DETECTION FOR CERVICAL CANCER SCREENING IN WOMEN PRESENTING WITH ABNORMAL CYTOLOGY IN LOKOJA, NIGERIA

Pages

  1-6

Abstract

 Background: Cervical cancer is regarded as the second highest cause of cancer deaths in Nigeria, with an overall prevalence similar to most developing countries. Screening for cervical cancer is primarily performed using papanicolaou (PAP) staining procedure, in Nigeria.Objectives: This study aimed to use human papillomavirus (HPV) DNA typing, as a means of ascertaining the presence of high risk HPV in cytology samples, which are positive for the presence of CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN), using the PAP screening procedure.Patients and Methods: Amplification of DNA was done using polymerase chain reaction. Gene sequencing was carried out to determine the presence of high risk HPV from cervical smears that were positive for abnormal cytology, from a cross-sectional study involving women between the ages of 16 - 65 years, screened for CIN and cervical cancer, in Lokoja, Nigeria.Results: Result showed a 100% presence of high risk HPV in all the samples with abnormal cytology. The HPV genotype 35 accounted for the highest percentage of the HPVs cases, with a 40% incidence. The HPV genotype 31 accounted for 30% of samples, while HPV genotype 16 and 18 accounted for 20% and 10% of samples, respectively.Conclusions: The high prevalence of HPV in abnormal cytology underlines to the fact that the presence of HPV is a critical factor in the development of cervical cancer. The use of HPV DNA techniques could actually become an effective and fast means of ascertaining the presence of HPV in abnormal cytology.

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    APA: Copy

    KOLAWOLE, OLATUNJI, OGAH, JEREMIAH, ALABI, OLATUNDE, SULEIMAN, MUSTAPHA, AMUDA, OLUWATOMI, & KOLAWOLE, FOLASHADE. (2015). UTILIZATION OF HUMAN PAPILLOMAVIRUS DNA DETECTION FOR CERVICAL CANCER SCREENING IN WOMEN PRESENTING WITH ABNORMAL CYTOLOGY IN LOKOJA, NIGERIA . JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(10), 1-6. SID. https://sid.ir/paper/317469/en

    Vancouver: Copy

    KOLAWOLE OLATUNJI, OGAH JEREMIAH, ALABI OLATUNDE, SULEIMAN MUSTAPHA, AMUDA OLUWATOMI, KOLAWOLE FOLASHADE. UTILIZATION OF HUMAN PAPILLOMAVIRUS DNA DETECTION FOR CERVICAL CANCER SCREENING IN WOMEN PRESENTING WITH ABNORMAL CYTOLOGY IN LOKOJA, NIGERIA . JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(10):1-6. Available from: https://sid.ir/paper/317469/en

    IEEE: Copy

    OLATUNJI KOLAWOLE, JEREMIAH OGAH, OLATUNDE ALABI, MUSTAPHA SULEIMAN, OLUWATOMI AMUDA, and FOLASHADE KOLAWOLE, “UTILIZATION OF HUMAN PAPILLOMAVIRUS DNA DETECTION FOR CERVICAL CANCER SCREENING IN WOMEN PRESENTING WITH ABNORMAL CYTOLOGY IN LOKOJA, NIGERIA ,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 10, pp. 1–6, 2015, [Online]. Available: https://sid.ir/paper/317469/en

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