مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CORRELATION BETWEEN MUCOSAL IL-6 MRNA EXPRESSION LEVEL AND VIRULENCE FACTORS OF HELICOBACTER PYLORI IN IRANIAN ADULT PATIENTS WITH CHRONIC GASTRITIS

Pages

  1-6

Abstract

 Background: HELICOBACTER PYLORI infection is associated with GASTRITIS and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells that contribute to sustained local inflammation. In this study, we sought to examine IL-6 expression in H. pylori-infected and uninfected gastric mucosa and elucidate the implication in the pathogenesis of H. pylori-associated GASTRITIS in human.Objectives: The current study aimed to determine mucosal IL-6 mRNA expression level and their correlation with VIRULENCE FACTORS and the grade of chronic GASTRITIS among H. pylori infected patients with chronic GASTRITIS from Shahrekord, Iran.Patients and Methods: Mucosal IL-6 mRNA levels was measured by real-time PCR using endoscopic biopsies taken from the gastric antrum of 58 subjects infected with H. pylori and 44 uninfected subjects. Presence of vacA and cagA VIRULENCE FACTORS was evaluated using PCR.Results: The IL-6 mRNA expression levels were significantly more elevated in H. pylori-positive patients than uninfected individuals and expression of this cytokine was independent from the VIRULENCE FACTORS. There was a correlation between IL-6 expression level and the grade of chronic GASTRITIS.Conclusions: Enhanced induction of IL-6 may be involved in the pathogenesis of H. pylori-associated GASTRITIS.

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    APA: Copy

    AZADEGAN DEHKORDI, FATEMEH, BAGHERI, NADER, SHIRZAD, MAHSA, SANEI, MOHAMMAD HOSSEIN, HASHEMZADEH CHALESHTORI, MORTEZA, RAFIEIAN KOPAEI, MAHMOUD, TABATABAIEFAR, MOHAMMAD AMIN, & SHIRZAD, HEDAYATOLLAH. (2015). CORRELATION BETWEEN MUCOSAL IL-6 MRNA EXPRESSION LEVEL AND VIRULENCE FACTORS OF HELICOBACTER PYLORI IN IRANIAN ADULT PATIENTS WITH CHRONIC GASTRITIS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(8), 1-6. SID. https://sid.ir/paper/317496/en

    Vancouver: Copy

    AZADEGAN DEHKORDI FATEMEH, BAGHERI NADER, SHIRZAD MAHSA, SANEI MOHAMMAD HOSSEIN, HASHEMZADEH CHALESHTORI MORTEZA, RAFIEIAN KOPAEI MAHMOUD, TABATABAIEFAR MOHAMMAD AMIN, SHIRZAD HEDAYATOLLAH. CORRELATION BETWEEN MUCOSAL IL-6 MRNA EXPRESSION LEVEL AND VIRULENCE FACTORS OF HELICOBACTER PYLORI IN IRANIAN ADULT PATIENTS WITH CHRONIC GASTRITIS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(8):1-6. Available from: https://sid.ir/paper/317496/en

    IEEE: Copy

    FATEMEH AZADEGAN DEHKORDI, NADER BAGHERI, MAHSA SHIRZAD, MOHAMMAD HOSSEIN SANEI, MORTEZA HASHEMZADEH CHALESHTORI, MAHMOUD RAFIEIAN KOPAEI, MOHAMMAD AMIN TABATABAIEFAR, and HEDAYATOLLAH SHIRZAD, “CORRELATION BETWEEN MUCOSAL IL-6 MRNA EXPRESSION LEVEL AND VIRULENCE FACTORS OF HELICOBACTER PYLORI IN IRANIAN ADULT PATIENTS WITH CHRONIC GASTRITIS,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 8, pp. 1–6, 2015, [Online]. Available: https://sid.ir/paper/317496/en

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