مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

339
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

184
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE

Pages

  0-0

Keywords

HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 

Abstract

 Background: Drug design against human immunodeficiency virus type 1 (HIV-1) INTEGRASE through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 INTEGRASE to be used as a model. A complete structure, similar to HIV-1 of a PROTOTYPE FOAMY VIRUS INTEGRASE in complex with DNA, including all conservative residues, is available and has been extensively used in recent investigations.Objectives: The aim of this study was to determine whether the above model is precisely representative of HIV-1 INTEGRASE. This would critically determine the success of any designed drug using the model in deactivation of INTEGRASE and AIDS treatment.Materials and Methods: Primarily, a new structure for HIV-1 was constructed, using a crystal structure of PROTOTYPE FOAMY VIRUS as the starting structure. The constructed structure of HIV-1 INTEGRASE was simultaneously simulated with a PROTOTYPE FOAMY VIRUS INTEGRASE on a separate occasion.Results: Our results indicate that the HIV-1 system behaves differently from the PROTOTYPE FOAMY VIRUS in terms of folding, hydration, hydrophobicity of binding site and stability.Conclusions: Based on our findings, we can conclude that HIV-1 INTEGRASE is vastly different from the PROTOTYPE FOAMY VIRUS INTEGRASE and does not resemble it, and the modeling output of the PROTOTYPE FOAMY VIRUS simulations could not be simply generalized to HIV-1 INTEGRASE. Therefore, our HIV-1 model seems to be more representative and more useful for future research.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    DAYER, MOHAMMAD REZA. (2016). COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(5), 0-0. SID. https://sid.ir/paper/317618/en

    Vancouver: Copy

    DAYER MOHAMMAD REZA. COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(5):0-0. Available from: https://sid.ir/paper/317618/en

    IEEE: Copy

    MOHAMMAD REZA DAYER, “COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317618/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button