ASSESSMENT OF THE HUMAN CYTOMEGALOVIRUS UL97 GENE FOR IDENTIFICATION OF RESISTANCE TO GANCICLOVIR IN IRANIAN IMMUNOSUPPRESSED PATIENTS

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KEYVANI HOSSEIN; TAGHINEZHAD SAROUKALAEI SEDIGHEH; MOHSENI AMIR HOSSEIN

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Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:5 Page(s): 0-0

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Title

ASSESSMENT OF THE HUMAN CYTOMEGALOVIRUS UL97 GENE FOR IDENTIFICATION OF RESISTANCE TO GANCICLOVIR IN IRANIAN IMMUNOSUPPRESSED PATIENTS

Author(s)

KEYVANI HOSSEIN | TAGHINEZHAD SAROUKALAEI SEDIGHEH | MOHSENI AMIR HOSSEIN | Issue Writer Certificate

Keywords

UL97 PROTEIN

HUMAN CYTOMEGALOVIRUS

GANCICLOVIR

IRAN

Abstract

Background: HUMAN CYTOMEGALOVIRUS (HCMV) infections are a major cause of morbidity and mortality among immunocom promised patients. Prolonged antiviral therapy is a cause of mutation and drug resistance in the HCMV genome.Objectives: The aim of this study was to identify resistance to GANCICLOVIR (GCV) in IRANian immunosuppressed patients at two different stages of the disease: early (before GCV is initiated) and late (after six months of GCV therapy).Patients and Methods: In this study, 87 specimens from IRANian patients were amplified using nested PCR amplification of the UL97 gene. Sequence analyses of products were performed for identifying the mutated codons.Results: The present study show that the most frequent GCV-resistant mutations occurred in codons A594V (26.43%), H520Q (18.39%), and M460V (13.79%), consequently occurring at a low frequency in the L595S (2.29%), E596G (1.14%), and Del 594 (1.14%) codons, and with intermediate frequency in the C592G (10.34%), M460I (9.19%), and C603W (6.89%) codons. We describe for the first time a new GCV-resistance mutation, the deletion of codon 594, in the UL97 gene of IRANian HCMV patients after GCV therapy, following renal transplantation.Conclusions: The findings of the present study can be utilized to detect GCV resistance patterns among IRANian immunocompromised patients and to treat HCMV infections accordingly.

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APA: Copy

KEYVANI, HOSSEIN, TAGHINEZHAD SAROUKALAEI, SEDIGHEH, & MOHSENI, AMIR HOSSEIN. (2016). ASSESSMENT OF THE HUMAN CYTOMEGALOVIRUS UL₉₇ GENE FOR IDENTIFICATION OF RESISTANCE TO GANCICLOVIR IN IRANIAN IMMUNOSUPPRESSED PATIENTS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(5), 0-0. SID. https://sid.ir/paper/317625/en

Vancouver: Copy

KEYVANI HOSSEIN, TAGHINEZHAD SAROUKALAEI SEDIGHEH, MOHSENI AMIR HOSSEIN. ASSESSMENT OF THE HUMAN CYTOMEGALOVIRUS UL₉₇ GENE FOR IDENTIFICATION OF RESISTANCE TO GANCICLOVIR IN IRANIAN IMMUNOSUPPRESSED PATIENTS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(5):0-0. Available from: https://sid.ir/paper/317625/en

IEEE: Copy

HOSSEIN KEYVANI, SEDIGHEH TAGHINEZHAD SAROUKALAEI, and AMIR HOSSEIN MOHSENI, “ASSESSMENT OF THE HUMAN CYTOMEGALOVIRUS UL₉₇ GENE FOR IDENTIFICATION OF RESISTANCE TO GANCICLOVIR IN IRANIAN IMMUNOSUPPRESSED PATIENTS,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317625/en

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