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Title

Antimicrobial and Antibiofilm Activity of Human Cationic Antibacterial Peptide (LL-37) and Its Analogs Against Pan-Drug-Resistant Acinetobacter baumannii

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Abstract

 Background: Human cationic antibacterial peptide hCAP18/LL-37 is the only known cathelicidin, which is part of the innate immune system of humans. The antimicrobial activity of LL-37 against multi-drug-resistant Acinetobacter baumannii has been reported recently, however, whether LL-37 and its analogues (LL/CAP18 and FF/CAP18) have antimicrobial activity against pan-drug-resistant Acinetobacter baumannii (PDRAB) is still unknown. Objectives: This study aims to clarify the antimicrobial activity of LL-37 and its analogues against PDRAB. Methods: In this study, we evaluated LL-37 and its truncated analogs inhibitory effect on the growth of PDRAB by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) analysis, we also examined the effect of LL-37 and its analogs on bacterial biofilm formation by using a quantitative crystal violet assay. Results: LL-37 and its truncated analogs were effective in inhibiting the growth of PDRAB and had a rapid killing ability. After exposure to the peptides, the development of the PDRAB biofilm was inhibited. Strong inhibitory and dispersion effects of FF/CAP18 on the biofilm were confirmed by fluorescence microscopy and field emission scanning electron microscopy. Conclusions: This results show that FF/CAP18 is a potential antimicrobial agent for treating pan-drug– resistant bacterial infections.

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    APA: Copy

    GUO, Yijie, WANG, LING, Lei, Jine, XU, JIRU, & Han, Lei. (2017). Antimicrobial and Antibiofilm Activity of Human Cationic Antibacterial Peptide (LL-37) and Its Analogs Against Pan-Drug-Resistant Acinetobacter baumannii. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 10(3), 0-0. SID. https://sid.ir/paper/317696/en

    Vancouver: Copy

    GUO Yijie, WANG LING, Lei Jine, XU JIRU, Han Lei. Antimicrobial and Antibiofilm Activity of Human Cationic Antibacterial Peptide (LL-37) and Its Analogs Against Pan-Drug-Resistant Acinetobacter baumannii. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2017;10(3):0-0. Available from: https://sid.ir/paper/317696/en

    IEEE: Copy

    Yijie GUO, LING WANG, Jine Lei, JIRU XU, and Lei Han, “Antimicrobial and Antibiofilm Activity of Human Cationic Antibacterial Peptide (LL-37) and Its Analogs Against Pan-Drug-Resistant Acinetobacter baumannii,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 10, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/317696/en

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