Antibacterial and Antioxidant Screening of Semi-Synthetic Naringin Based Hydrazone and Oxime Derivatives

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Jaradat Nidal; Shawarb Nuha; Hussein Fatima; Al Masri Motasem; Warad Ismail; Khasati Ahmad; Shehadeh Mayadah; Qneibi Mohammad; Ali Hussein Azmi Mahmoud; Makhamreh Sabha

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Journal: Jundishapur Journal of Microbiology Year:2018 | Volume:11 | Issue:6 Page(s): 0-0

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Title

Antibacterial and Antioxidant Screening of Semi-Synthetic Naringin Based Hydrazone and Oxime Derivatives

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Keywords

Anti-Bacterial Agents

Antioxidants

Naringin

Oxime

Hydrazone

Abstract

Background: The semi-synthesis of drugs from natural products is still limited and complicated. Recently, there has been compelling global need to develop novel and potential antibacterial and antioxidant agents. Objectives: The current study aimed at semi-synthesizing new derivatives from Naringin, to verify their chemical structures and assess their antibacterial and antioxidant potentials. Methods: The semi-synthesis of Naringin was conducted in the presence of Hydrazone and Oxime derivatives in acidic solution, while elemental and spectral analytical methods were used to verify the chemical structures of the semi-synthesized molecules. Also, to assess their antibacterial activity, the micro-broth dilution method with different American type culture collection (ATCC) strains as Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and clinical isolate methicillin-resistant Staphylococcus aureus (MRSA) were utilized. Moreover, 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) was used to assess the antioxidant activity of the derived compounds. Results: Three new Hydrazone and Oxime compounds were semi-synthesized from Naringin and their chemical structures were identified by 13CNMR, IR, MS, and 1HNMR. Amongthe semi-synthesized compounds, the (2a) molecule showed the best antibacterial activity with a minimum inhibitory concentration (MIC) value of 62. 5 g/mL. Also, this compound exhibited the best antioxidant activity with IC50 3. 7 g/mL, in comparison with the other studied samples. Conclusions: Hydrazone (2a) compound could be used as a potent antioxidant and bacterial agent. Further studies are required to investigate other therapeutic effects of the (2a) molecule.

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APA: Copy

Jaradat, Nidal, Shawarb, Nuha, Hussein, Fatima, Al Masri, Motasem, Warad, Ismail, Khasati, Ahmad, Shehadeh, Mayadah, Qneibi, Mohammad, Ali Hussein, Azmi Mahmoud, & Makhamreh, Sabha. (2018). Antibacterial and Antioxidant Screening of Semi-Synthetic Naringin Based Hydrazone and Oxime Derivatives. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 11(6), 0-0. SID. https://sid.ir/paper/317745/en

Vancouver: Copy

Jaradat Nidal, Shawarb Nuha, Hussein Fatima, Al Masri Motasem, Warad Ismail, Khasati Ahmad, Shehadeh Mayadah, Qneibi Mohammad, Ali Hussein Azmi Mahmoud, Makhamreh Sabha. Antibacterial and Antioxidant Screening of Semi-Synthetic Naringin Based Hydrazone and Oxime Derivatives. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2018;11(6):0-0. Available from: https://sid.ir/paper/317745/en

IEEE: Copy

Nidal Jaradat, Nuha Shawarb, Fatima Hussein, Motasem Al Masri, Ismail Warad, Ahmad Khasati, Mayadah Shehadeh, Mohammad Qneibi, Azmi Mahmoud Ali Hussein, and Sabha Makhamreh, “Antibacterial and Antioxidant Screening of Semi-Synthetic Naringin Based Hydrazone and Oxime Derivatives,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 11, no. 6, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/317745/en

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