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Information Journal Paper

Title

Resistance of Candida albicans Biofilms to Drugs and the Host Immune System

Pages

  0-0

Abstract

 Background: Candida albicans is a commensal fungus that resides on mucosal surfaces and in the gastrointestinal and genitourinary tracts in humans. However, it can cause an infection when the immune system of the host is impaired or if a niche becomes available. Many C. albicans infections are due to the organism’ s ability to form a biofilm on implanted medical devices. A biofilm represents an optimal medium for the growth of C. albicans as it allows cells to be enclosed by a self-produced extracellular matrix (ECM). Objectives: The present work investigated certain aspects of the resistance of C. albicans Biofilms to drugs and the host immune system. Results: An ECM was found to provide the infrastructure for biofilm formation, prevent disaggregation, and shield encapsulated C. albicans cells from antifungal drugs and the host’ s immune system. By influencing FKS1 and upregulating multiple glucan modification genes, -1, 3-glucan, an important component of ECM, was shown to be responsible for many of the biofilm’ s drug-resistant properties. On being engulfed by ECM, the fungal cell was found to switch from glycolysis to gluconeogenesis. Resembling the cellular response to starvation, this was followed by the activation of the glyoxylate cycle that allowed the use of simple molecules as energy sources. Conclusion: Mature Biofilms were found to be much more resistant to antifungal agents and the host immune system than free cells. The factors responsible for high resistance included the complex architecture of Biofilms, ECM, increased expression of drug efflux pumps, and metabolic plasticity.

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    • Cite

    APA: Copy

    SANDAI, DOBLIN, Tabana, YasserM., El Ouweini, Ahmad, & Ayodeji, Ishola Oluwaseun. (2016). Resistance of Candida albicans Biofilms to Drugs and the Host Immune System. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(11), 0-0. SID. https://sid.ir/paper/317755/en

    Vancouver: Copy

    SANDAI DOBLIN, Tabana YasserM., El Ouweini Ahmad, Ayodeji Ishola Oluwaseun. Resistance of Candida albicans Biofilms to Drugs and the Host Immune System. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(11):0-0. Available from: https://sid.ir/paper/317755/en

    IEEE: Copy

    DOBLIN SANDAI, YasserM. Tabana, Ahmad El Ouweini, and Ishola Oluwaseun Ayodeji, “Resistance of Candida albicans Biofilms to Drugs and the Host Immune System,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317755/en

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