Carbapenem Susceptibility and Multidrug-Resistance in Pseudomonas aeruginosa Isolates in Egypt

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Hashem Hany; Hanora Amro; Abdalla Salah; Shawky Alaa; Saad Alaa

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Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:11 Page(s): 0-0

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Title

Carbapenem Susceptibility and Multidrug-Resistance in Pseudomonas aeruginosa Isolates in Egypt

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Keywords

Pseudomonas aeruginosa

MBLs

Amp C

MDR

Abstract

Background: Resistant Pseudomonas aeruginosa is a serious concern for antimicrobial therapy, as the common isolates exhibit variable grades of resistance, involving beta-lactamase enzymes, beside native defense mechanisms. Objectives: The present study was designed to determine the occurrence of Metallo--Lactamases (MBL) and Amp C harboring P. aeruginosa isolates from Suez Canal university hospital in Ismailia, Egypt. Methods: A total of 147 P. aeruginosa isolates, recovered from 311 patients during a 10-month period, were collected between May 2013 and February 2014; the isolates were collected from urine, wound and sputum. Minimum inhibitory concentration (MIC) determined by agar dilution methods was 2 g/mL for meropenem and imipenem. Identification of P. aeruginosa was confirmed using API 20NE. Metallo--Lactamases and Amp C were detected based on different phenotypic methods. Results: Overall, 26. 5% of P. aeruginosa isolates (39/147) were carbapenem resistant isolates. Furthermore, 64. 1% (25/39) were MBL producers, these isolates were screened by the combined disc and disc diffusion methods to determine the ability of MBL production. Both MBL andAmpC harbored P. aeruginosa isolates were 28% (7/25). Sixty-four percent of P. aeruginosa isolates were multidrug resistant (MDR) (16/25). The sensitivity toward polymyxin, imipenem, norfloxacin, piperacillin-tazobactam and gentamicin was 99%, 91%, 88%, 82% and 78%, respectively. The resistance rate towards cefotaxime, ceftazidime, cefepime, aztreonam and meropenem was 98. 6%, 86%, 71. 4%, 34% and 30%, respectively. Conclusions: Multidrug resistance was significantly associated with MBL production in P. aeruginosa. Early detection of MBLproducing P. aeruginosa and hospital antibiotic policy prescription helps proper antimicrobial therapy and avoidance of dissemination of these multidrug resistance isolates.

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APA: Copy

Hashem, Hany, Hanora, Amro, Abdalla, Salah, Shawky, Alaa, & Saad, Alaa. (2016). Carbapenem Susceptibility and Multidrug-Resistance in Pseudomonas aeruginosa Isolates in Egypt. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(11), 0-0. SID. https://sid.ir/paper/317756/en

Vancouver: Copy

Hashem Hany, Hanora Amro, Abdalla Salah, Shawky Alaa, Saad Alaa. Carbapenem Susceptibility and Multidrug-Resistance in Pseudomonas aeruginosa Isolates in Egypt. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(11):0-0. Available from: https://sid.ir/paper/317756/en

IEEE: Copy

Hany Hashem, Amro Hanora, Salah Abdalla, Alaa Shawky, and Alaa Saad, “Carbapenem Susceptibility and Multidrug-Resistance in Pseudomonas aeruginosa Isolates in Egypt,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317756/en

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