The Prevalence of SEN Virus and Occult Hepatitis B (OBI) Virus Infection Among Blood Donors in Ahvaz City

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ABBASI SAMANEH; MAKVANDI MANOCHEHR; KARIMI GHARIB; NEISI NILOOFAR

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Paper Information

Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:7 Page(s): 0-0

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Title

The Prevalence of SEN Virus and Occult Hepatitis B (OBI) Virus Infection Among Blood Donors in Ahvaz City

Author(s)

ABBASI SAMANEH | MAKVANDI MANOCHEHR | KARIMI GHARIB | NEISI NILOOFAR | Issue Writer Certificate

Keywords

SEN Virus

Chronic Hepatitis B Infection

Transfusion Transmitted Virus

Blood Donor

Polymerase Chain Reaction

Abstract

Background: The SEN Virus (SENV) is a prevalent blood borne pathogen that has a worldwide incidence. SENV is comprised of eight genotypes; genotypesHandDare frequently associatedwith the pathogenesis of non-A-E hepatitisandpost-transfusion hepatitis in Blood Donors and hepatitis patients. So far, no SENV pathogenesis has been reported in the liver biopsies of SENV carriers, but the frequency of SENV and its related genotypes requires further molecular epidemiology studies in different regions of the world. Occult hepatitis B infection (OBI) is another global public health problem that is primarily transmitted via blood transfusions. Therefore, the identification of OBI among Blood Donors is key to preventing the spread of this disease. The relationship between SENV and OBI requires further evaluation. Objectives: The aim of this study was to determine the prevalence of SENV-D and SENV-H in Blood Donors in Ahvaz city with a particular focus on co-infection with OBI. Patients and Methods: This study had a cross-sectional design and included 184 healthy consecutive Blood Donors who visited a blood transfusion center in Ahvaz city from October-November 2013. The sera of all Blood Donors negative for HBsAg, anti-HCV antibody, and anti-HIV antibody were tested for SENV-D and SENV-H using nested Polymerase Chain Reaction (PCR). In addition, tests for HBV DNA (PCR), HBcIgG (ELISA), liver function (aspartate transaminase and alanine transaminase), and alkaline phosphatase were carried out. Results: Liver function tests in the healthy Blood Donors were within the normal range. The incidence rates of SENV-D and SENVH in the 184 total Blood Donors were 10 (5. 4%) (95% confidence interval (CI): 2. 1%-9. 0%) and 32 (17. 4%) cases (95% CI: 12. 0%-23. 0%), respectively. SENV-H/D co-infection occurred in 2 (1. 1%) patients. The sera of 8/184 (4. 3%) were positive for anti-HBc antibody but negative for HBV DNA. Conclusions: Regardless of the presence of nonpathogenic SENV, 44/184 (24%) Blood Donors tested positive for both SENV-D and SENV-H. Although 4. 3% of Blood Donors were positive for HBcIgG but negative for HBV DNA, the presence of OBI cannot be ruled out unless their liver biopsies show negative for HBV DNA.

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APA: Copy

ABBASI, SAMANEH, MAKVANDI, MANOCHEHR, KARIMI, GHARIB, & NEISI, NILOOFAR. (2016). The Prevalence of SEN Virus and Occult Hepatitis B (OBI) Virus Infection Among Blood Donors in Ahvaz City. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(7), 0-0. SID. https://sid.ir/paper/317764/en

Vancouver: Copy

ABBASI SAMANEH, MAKVANDI MANOCHEHR, KARIMI GHARIB, NEISI NILOOFAR. The Prevalence of SEN Virus and Occult Hepatitis B (OBI) Virus Infection Among Blood Donors in Ahvaz City. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(7):0-0. Available from: https://sid.ir/paper/317764/en

IEEE: Copy

SAMANEH ABBASI, MANOCHEHR MAKVANDI, GHARIB KARIMI, and NILOOFAR NEISI, “The Prevalence of SEN Virus and Occult Hepatitis B (OBI) Virus Infection Among Blood Donors in Ahvaz City,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317764/en

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