Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran

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NAJAFI SAEIDEH; GHANE MASOOD; POORTAHMASEBI VAHDAT; JAZAYERI SEYED MOHAMMAD; YOUSEFZADEH CHABOK SHAHROKH

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Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:7 Page(s): 0-0

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Title

Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran

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Keywords

Multiple Sclerosis

Cytomegalovirus

Autoimmune Disease

Abstract

Background: Multiple Sclerosis (MS) is a chronic debilitating diseaseknown as one of the mostcommonneurological dysfunctions in young adults. Recent studies suggest that infections with herpesviruses play a critical role in the pathogenesis of MS. Objectives: The present investigation aimed to detect the presence of Cytomegalovirus (CMV) in patients withMSusing polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) methods. Patients and Methods: Plasma and peripheral blood mononuclear cells (PBMCs) were collected from MS patients (n = 82) and from blood donors as control group (n = 89). They were tested for the presence of CMV antibodies and DNA by ELISA and PCR, respectively. Results: Anti-CMV was positive in 65 (79. 3%) and 69 (77. 5%) of the MS patients and healthy subjects, respectively (P= 0. 853). Similarly, 23 (28%) and 2 (2. 2%) patients were positive for CMV DNA among the MS and control groups, respectively. Statistical analysis showed that the frequency of CMV DNA in the MS patients was significantly higher than in the healthy controls (P < 0. 001). Conclusions: The results of this study showed a possible association between CMV infection and MS. Further experimental and epidemiological studies using case-control approaches are needed to confirm this association.

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APA: Copy

NAJAFI, SAEIDEH, GHANE, MASOOD, POORTAHMASEBI, VAHDAT, JAZAYERI, SEYED MOHAMMAD, & YOUSEFZADEH CHABOK, SHAHROKH. (2016). Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(7), 0-0. SID. https://sid.ir/paper/317766/en

Vancouver: Copy

NAJAFI SAEIDEH, GHANE MASOOD, POORTAHMASEBI VAHDAT, JAZAYERI SEYED MOHAMMAD, YOUSEFZADEH CHABOK SHAHROKH. Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(7):0-0. Available from: https://sid.ir/paper/317766/en

IEEE: Copy

SAEIDEH NAJAFI, MASOOD GHANE, VAHDAT POORTAHMASEBI, SEYED MOHAMMAD JAZAYERI, and SHAHROKH YOUSEFZADEH CHABOK, “Prevalence of Cytomegalovirus in Patients With Multiple Sclerosis: A Case-Control Study in Northern Iran,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317766/en

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