Biological Evaluation of Endophytic Fungus Chaetomium sp. NF15 of Justicia adhatoda L.: A Potential Candidate for Drug Discovery

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Fatima Nighat; Mukhtar Usman; Ul Haq Ihsan; Qazi Muneer Ahmed; Jadoon Muniba; Ahmed Safia

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Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:6 Page(s): 0-0

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Title

Biological Evaluation of Endophytic Fungus Chaetomium sp. NF15 of Justicia adhatoda L.: A Potential Candidate for Drug Discovery

Author(s)

Keywords

Antimicrobial

Antioxidant

Endophytes

Chaetomium sp.

Justicia adhatoda L

Abstract

Background: The Endophytes of medicinal plants, such as Justicia adhatoda L., represent a promising and largely underexplored domain that is considered as a repository of biologically active compounds. Objectives: The aim of present study was isolation, identification, and biological evaluation of endophytic fungi associated with the J. adhatoda L. plant for the production of Antimicrobial, Antioxidant, and cytotoxic compounds Materials and Methods: Endophytic fungi associated with the J. adhatoda L. plant were isolated from healthy plant parts and taxonomically characterized through morphological, microscopic, and 18S rDNA sequencing methods. The screening for bioactive metabolite production was achieved using ethyl acetate extracts, followed by the optimization of different parameters for maximum production of bioactive metabolites. Crude and partially purified extracts were used to determine the Antimicrobial, Antioxidant, and cytotoxic potential Results: Out of six endophytic fungal isolates, Chaetomium sp. NF15 showed the most promising biological activity and was selected for detailed study. The crude ethyl acetate extract of NF15 isolate after cultivation under optimized culture conditions showed promising Antimicrobial activity, with significant inhibition of the clinical isolates of Staphylococcus aureus (87%, n=42), Pseudomonas aeruginosa (> 85%, n = 41), and Candida albicans (62%, n = 24). Conclusions: The present study confirms the notion of selecting endophytic fungi of medicinal plant Justicia for the bioassayguided isolation of its bioactive compounds, and demonstrates that endophytic fungus Chaetomium sp. NF15 could be a potential source of bioactive metabolites.

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APA: Copy

Fatima, Nighat, Mukhtar, Usman, Ul Haq, Ihsan, Qazi, Muneer Ahmed, Jadoon, Muniba, & Ahmed, Safia. (2016). Biological Evaluation of Endophytic Fungus Chaetomium sp. NF15 of Justicia adhatoda L.: A Potential Candidate for Drug Discovery. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(6), 0-0. SID. https://sid.ir/paper/317889/en

Vancouver: Copy

Fatima Nighat, Mukhtar Usman, Ul Haq Ihsan, Qazi Muneer Ahmed, Jadoon Muniba, Ahmed Safia. Biological Evaluation of Endophytic Fungus Chaetomium sp. NF15 of Justicia adhatoda L.: A Potential Candidate for Drug Discovery. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(6):0-0. Available from: https://sid.ir/paper/317889/en

IEEE: Copy

Nighat Fatima, Usman Mukhtar, Ihsan Ul Haq, Muneer Ahmed Qazi, Muniba Jadoon, and Safia Ahmed, “Biological Evaluation of Endophytic Fungus Chaetomium sp. NF15 of Justicia adhatoda L.: A Potential Candidate for Drug Discovery,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 6, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317889/en

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