Inhibitory effect of BMAP-28 on Leptospiral Lipopolysaccharide-Induced TLR2-Dependent Immune Response in Bovine Cells

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GUO Yijie; Ding Cuiping; ZHANG BO; XU Jun; XUN Meng; XU JIRU

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Journal Paper

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Journal: Jundishapur Journal of Microbiology Year:2016 | Volume:9 | Issue:6 Page(s): 0-0

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Title

Inhibitory effect of BMAP-28 on Leptospiral Lipopolysaccharide-Induced TLR2-Dependent Immune Response in Bovine Cells

Author(s)

Keywords

LPS

Toll-Like Receptor 2

Cytokines

BMAP-28

Cattle

Leptospira

Abstract

Background: Bovine leptospirosis is a widespread zoonotic disease, leading to serious economic losses in animal production and causing potential hazards to human health. Leptospiral lipopolysaccharide (L-LPS) plays an important role in leptospirosis pathogenicity. Objectives: With respect to L-LPS endotoxin-like activity, we examined bovine immune response to L-LPS and the inhibitory ability of bovine myeloid antimicrobial peptide-28 (BMAP-28) against L-LPS-induced immune activation in bovine cells. Materials and Methods: In this study, L-LPS-induced proinflammatory cytokine production in bovine cells was quantitatively measured with real-time PCR and ELISA, and we determined which cell membrane receptors (toll-like receptor [TLR]2 and TLR4) played a major role. In addition, the ability of BMAP-28 to inhibit L-LPS-induced endotoxin-like immune activation in bovine cells was determined by the decrease in cytokine secretion. Results: L-LPS showed the ability to induce cytokine production in bovine cells, and its induction was TLR2-dependent. BMAP-28 was used to inhibit L-LPS-induced endotoxin-like activity. The function of BMAP-28 was to inhibit LPS-induced TLR2 expression and cytokine production. Conclusions: In this study, the L-LPS immune response of bovine cells was significant, indicating that TLR2 is the predominant receptor for L-LPS. Due to L-LPS endotoxin-like activity, we found a strategy through using BMAP-28 to prevent L-LPS-induced TLR2-dependent immune activation in bovine cells.

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APA: Copy

GUO, Yijie, Ding, Cuiping, ZHANG, BO, XU, Jun, XUN, Meng, & XU, JIRU. (2016). Inhibitory effect of BMAP-28 on Leptospiral Lipopolysaccharide-Induced TLR2-Dependent Immune Response in Bovine Cells. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(6), 0-0. SID. https://sid.ir/paper/317893/en

Vancouver: Copy

GUO Yijie, Ding Cuiping, ZHANG BO, XU Jun, XUN Meng, XU JIRU. Inhibitory effect of BMAP-28 on Leptospiral Lipopolysaccharide-Induced TLR2-Dependent Immune Response in Bovine Cells. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(6):0-0. Available from: https://sid.ir/paper/317893/en

IEEE: Copy

Yijie GUO, Cuiping Ding, BO ZHANG, Jun XU, Meng XUN, and JIRU XU, “Inhibitory effect of BMAP-28 on Leptospiral Lipopolysaccharide-Induced TLR2-Dependent Immune Response in Bovine Cells,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 6, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317893/en

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