The Effect of Ubiquitin Like Protein-Proteasome System on the Drug Resistance of Isoniazid Mono-Resistant Mycobacterium tuberculosis

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ZHANG SHUAI; Zhang Shun Wen; Wu Jiang Dong; ZHANG JIE; Dong Jiang Tao; ZHU HUI YUN; WU FANG; Zhang Wan Jiang

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Journal: Jundishapur Journal of Microbiology Year:2018 | Volume:11 | Issue:2 Page(s): 0-0

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Title

The Effect of Ubiquitin Like Protein-Proteasome System on the Drug Resistance of Isoniazid Mono-Resistant Mycobacterium tuberculosis

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Keywords

Isoniazid

Drug Resistance

Mycobacterium Tuberculosis

Pup

Abstract

Background: Tuberculosis (TB) is one of the most widespread and lethal infectious diseases worldwide. The emergence of drugresistant TB has hampered effective TB treatment and control. Prokaryotic ubiquitin-like Protein-Proteasome System (PPS) contributes to the survival of Mycobacterium Tuberculosis in the host. However, whether PPS effects Drug Resistance of Isoniazid monoresistant Mycobacterium Tuberculosis (INH-MTB) is still unknown. Objectives: This study aimed at exploring the effect of PPS on Drug Resistance of INH-MTB strain. Methods: In this study, over-expression of strains and deletion of mutant strains were constructed using electroporation. The researchers identified these constructed strains by Quantitative Reverse Transcription Polymerase Chain Reaction (RT-qPCR) or PCR. The Minimum Inhibitory Concentration (MIC) of Isoniazid in INH-MTB strain and its derivative PPS mutant strains were determined using the Resazurin micro-titre assay. Results: The MIC of Isoniazid was 8 g/mL higher in INH-MTB with Pup over-expression strain than that in INH-MTB. The MIC of Isoniazid was 4. 82 g/mL, 4. 98 g/mL, 4. 99 g/mL, and 4. 9 g/mL lower in INH-MTB with deletion of Pup, Dop, PafA or Mpa strains than that in INH-MTB, respectively. The differences had statistical significance (P < 0. 05). The MIC of Isoniazid was 1. 03 g/mL higher in INH-MTB with PafA over-expression strain than that in INH-MTB. The MIC of Isoniazid was 1. 03 g/mL and 0. 68 g/mL lower in INH-MTB with Dop, Mpa over-expression strains than that in INH-MTB, respectively. The differences had no statistical significance (P > 0. 05). Conclusions: These results show that PPS effects the Drug Resistance of the INH-MTB strain.

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APA: Copy

ZHANG, SHUAI, Zhang, Shun Wen, Wu, Jiang Dong, ZHANG, JIE, Dong, Jiang Tao, ZHU, HUI YUN, WU, FANG, & Zhang, Wan Jiang. (2018). The Effect of Ubiquitin Like Protein-Proteasome System on the Drug Resistance of Isoniazid Mono-Resistant Mycobacterium tuberculosis. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 11(2), 0-0. SID. https://sid.ir/paper/317943/en

Vancouver: Copy

ZHANG SHUAI, Zhang Shun Wen, Wu Jiang Dong, ZHANG JIE, Dong Jiang Tao, ZHU HUI YUN, WU FANG, Zhang Wan Jiang. The Effect of Ubiquitin Like Protein-Proteasome System on the Drug Resistance of Isoniazid Mono-Resistant Mycobacterium tuberculosis. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2018;11(2):0-0. Available from: https://sid.ir/paper/317943/en

IEEE: Copy

SHUAI ZHANG, Shun Wen Zhang, Jiang Dong Wu, JIE ZHANG, Jiang Tao Dong, HUI YUN ZHU, FANG WU, and Wan Jiang Zhang, “The Effect of Ubiquitin Like Protein-Proteasome System on the Drug Resistance of Isoniazid Mono-Resistant Mycobacterium tuberculosis,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 11, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/317943/en

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