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Information Journal Paper

Title

EFFECT OF POMEGRANATE JUICE ON PARAOXONASE ENZYME ACTIVITY IN PATIENTS WITH TYPE 2 DIABETES

Pages

  26-31

Abstract

 OBJECTIVE: The aim of this study was to investigate the effect of POMEGRANATE JUICE (PJ) on the paraoxonase and arylesterase activity of human serum paraoxonase(PON1).MATERIAL AND METHOD: Fifty patients with type 2 DIABETES MELLITUS consumed 200 ml of PJ daily for a period of 6 weeks. Blood was collected from the patients before and after PJ consumption after 12 h of fasting. Blood sugar, total cholesterol, triglyceride, and HDL-C were measured by enzymatic kit method and auto analyzer. The concentration of LDL-C was calculated by using Friedwald formula. The malondialdehyde concentration (mmol/L) was determined by thiobarbituric acid (TBA) assay. Paraoxonase and arylesterase activity of PON1 enzyme were measured using paraoxone and phenylacetate as the substrates.RESULTS: The concentration of fasting blood sugar, total cholesterol, LDL-C and malondialdehyde significantly (p<0.001) decreased after the intervention. Paraoxonase and arylesterase activity of PON1 significantly (p<0.001) increased after the intervention. However, there were no significant changes in serum triglyceride and HDL-C. There was a significant positive correlation between paraoxonase and arylesterase activity of PON1 and serum HDL-C concentration. A significant negative correlation was detected between paraoxonase and arylesterase activity of PON1 and FBS. CONCLUSION: It can be concluded that PJ consumption as an antioxidant may have a contribution in changing fasting blood sugar, lipid profiles, lipoprotein oxidation, and PON1 ACTIVITY.

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    APA: Copy

    PARSAEYAN, NAYEREH, MOZAFFARI KHOSRAVI, HASSAN, & MOZAYAN, MOHAMMAD REZA. (2012). EFFECT OF POMEGRANATE JUICE ON PARAOXONASE ENZYME ACTIVITY IN PATIENTS WITH TYPE 2 DIABETES. IRANIAN JOURNAL OF DIABETES AND OBESITY, 4(1), 26-31. SID. https://sid.ir/paper/318134/en

    Vancouver: Copy

    PARSAEYAN NAYEREH, MOZAFFARI KHOSRAVI HASSAN, MOZAYAN MOHAMMAD REZA. EFFECT OF POMEGRANATE JUICE ON PARAOXONASE ENZYME ACTIVITY IN PATIENTS WITH TYPE 2 DIABETES. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2012;4(1):26-31. Available from: https://sid.ir/paper/318134/en

    IEEE: Copy

    NAYEREH PARSAEYAN, HASSAN MOZAFFARI KHOSRAVI, and MOHAMMAD REZA MOZAYAN, “EFFECT OF POMEGRANATE JUICE ON PARAOXONASE ENZYME ACTIVITY IN PATIENTS WITH TYPE 2 DIABETES,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 4, no. 1, pp. 26–31, 2012, [Online]. Available: https://sid.ir/paper/318134/en

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