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Information Journal Paper

Title

The Effects of High Intensity Interval Training on HNF-4 α Gene Expression in Liver Tissue of Type 2 Diabetic Male Wistar Rats

Pages

  210-215

Abstract

 Objective: This study examined the effect of high intensity interval training (HIIT) on HNF-4α gene expression, glucose and insulin in liver tissue of Type 2 diabetic male Wistar rats. Materials and Methods: In this study, 20 male Wistar rats weighing 220 (± 20) grams were selected. After type 2 diabetes (T2D) induction, the samples were divided into two groups of HIIT and control. The training program was 12 weeks and 5 times a week. Fasting glucose, serum insulin and HNF-4α gene expression in the liver tissue were measured in both groups after the last exercise session by using independent T-test. Results: The results showed that HIIT decreased significantly the fasting glucose (P-value: 0. 001) and increased serum insulin (Pvalue: 0. 001). Also, the expression of HNF-4α after HIIT significantly decreased in comparison to the control group (P-value: 0. 003). Conclusion: Based on the findings, HIIT resulted in a significant decrease in fasting glucose and a significant increase in insulin that is likely to reduce the liver HNF-4α gene expression of T2D male Wistar rats by increasing serum insulin.

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    APA: Copy

    Yadegari, Elham, BANAEIFAR, ABDOLALI, AZARBAYJANI, MOHAMAD ALI, & ARSHADI, SAJAD. (2018). The Effects of High Intensity Interval Training on HNF-4 α Gene Expression in Liver Tissue of Type 2 Diabetic Male Wistar Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY, 10(4), 210-215. SID. https://sid.ir/paper/318239/en

    Vancouver: Copy

    Yadegari Elham, BANAEIFAR ABDOLALI, AZARBAYJANI MOHAMAD ALI, ARSHADI SAJAD. The Effects of High Intensity Interval Training on HNF-4 α Gene Expression in Liver Tissue of Type 2 Diabetic Male Wistar Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2018;10(4):210-215. Available from: https://sid.ir/paper/318239/en

    IEEE: Copy

    Elham Yadegari, ABDOLALI BANAEIFAR, MOHAMAD ALI AZARBAYJANI, and SAJAD ARSHADI, “The Effects of High Intensity Interval Training on HNF-4 α Gene Expression in Liver Tissue of Type 2 Diabetic Male Wistar Rats,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 10, no. 4, pp. 210–215, 2018, [Online]. Available: https://sid.ir/paper/318239/en

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