THE EFFECT OF NIMODIPINE ON MEMORY LOSS FOLLOWING NALOXONE-INDUCED MORPHINE WITHDRAWAL IN OBJECT RECOGNITION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VASEGHI G.; HAJHASHEMI V.; RABBANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2014 | Volume:9 | Issue:6 Page(s): 445-451

Download Full-Text

View:

301

Download:

113

Cites:

Information Journal Paper

Title

THE EFFECT OF NIMODIPINE ON MEMORY LOSS FOLLOWING NALOXONE-INDUCED MORPHINE WITHDRAWAL IN OBJECT RECOGNITION

Author(s)

VASEGHI G. | HAJHASHEMI V. | RABBANI M. | Issue Writer Certificate

Keywords

NALOXONE

MORPHINE WITHDRAWAL

MEMORY PERFORMANCE

NIMODIPINE

CORTICOSTERONE

Abstract

We have previously evaluated the effect of NIMODIPINE, L-type calcium channel blocker, on memory loss during spontaneous MORPHINE WITHDRAWAL. In the present study the effect of NIMODIPINE on memory loss in NALOXONE-induced MORPHINE WITHDRAWAL mice was investigated. Mice were made dependent by increasing doses of morphine for three days. Object recognition task that was used for evaluation of MEMORY PERFORMANCE comprised of three sections: 15 min habitation, 12 min first trial and 5 min test trial. NALOXONE was injected 3 h after the administration of the last dose of morphine. Recognition index was evaluated 20 min after NALOXONE injection. NIMODIPINE was administrated in repeated form (1, 5 and 10 mg/kg) with daily doses of morphine or as a single injection (5 and 10 mg/kg) on the last day. Both acute and repeated treatments with NIMODIPINE prevented the memory impairment in NALOXONE-induced MORPHINE WITHDRAWAL mice (P<0.05 comparison of acute and repeated treatment data with their corresponding control values). CORTICOSTERONE concentration was significantly increased in the brain and blood of the mice during withdrawal. Pretreatment with NIMODIPINE, however, decreased the CORTICOSTERONE concentration in both brain and blood. The present study showed that NIMODIPINE prevents intense memory loss following NALOXONEinduced MORPHINE WITHDRAWAL.

Cites

No record.

References

No record.

Cite

APA: Copy

VASEGHI, G., HAJHASHEMI, V., & RABBANI, M.. (2014). THE EFFECT OF NIMODIPINE ON MEMORY LOSS FOLLOWING NALOXONE-INDUCED MORPHINE WITHDRAWAL IN OBJECT RECOGNITION. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(6), 445-451. SID. https://sid.ir/paper/318373/en

Vancouver: Copy

VASEGHI G., HAJHASHEMI V., RABBANI M.. THE EFFECT OF NIMODIPINE ON MEMORY LOSS FOLLOWING NALOXONE-INDUCED MORPHINE WITHDRAWAL IN OBJECT RECOGNITION. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2014;9(6):445-451. Available from: https://sid.ir/paper/318373/en

IEEE: Copy

G. VASEGHI, V. HAJHASHEMI, and M. RABBANI, “THE EFFECT OF NIMODIPINE ON MEMORY LOSS FOLLOWING NALOXONE-INDUCED MORPHINE WITHDRAWAL IN OBJECT RECOGNITION,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 9, no. 6, pp. 445–451, 2014, [Online]. Available: https://sid.ir/paper/318373/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops