THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAGHIPOUR B.; YAKHCHALI M.; HARIRIAN I.; TAMADDON A.M.; MOHAMMADI SAMANI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2014 | Volume:9 | Issue:6 Page(s): 407-420

Download Full-Text

View:

305

Download:

Cites:

Information Journal Paper

Title

THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS

Author(s)

Keywords

PROTEIN

DRUG DELIVERY

BIODEGRADABLE

PLGA

NANOCOMPOSITE

Abstract

Double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. In this study various parameters including technical and compositional variables were considered to achieve an optimized formulation with desire characteristics especially size and the release profiles, using high shear homogenizer. In this regard, bovine serum albumin (BSA) was used as the model PROTEIN and double emulsion was formed with the addition of Tween 80 and Span 80 as surfactants for inner aqueous phase and oil phase, respectively. Hydroxypropyl beta cyclodextrin was used as PROTEIN stabilizer. After optimization steps, composite nanoparticles (core-shell) were made based on optimized formulation by hyaluronic acid as shell and poly lactic-co-glycolic acid (PLGA) as core material. Formulation of the BSA loaded PLGA nanoparticles using core shell strategy improved the release pattern of the BSA and diminished burst release. The final composite nanoparticles had the particle size of about 160 nm and 70 % of the loaded BSA was released during 14 days and the release data was better fitted to zero order release kinetics.

Cites

No record.

References

No record.

Cite

APA: Copy

TAGHIPOUR, B., YAKHCHALI, M., HARIRIAN, I., TAMADDON, A.M., & MOHAMMADI SAMANI, S.. (2014). THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(6), 407-420. SID. https://sid.ir/paper/318376/en

Vancouver: Copy

TAGHIPOUR B., YAKHCHALI M., HARIRIAN I., TAMADDON A.M., MOHAMMADI SAMANI S.. THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2014;9(6):407-420. Available from: https://sid.ir/paper/318376/en

IEEE: Copy

B. TAGHIPOUR, M. YAKHCHALI, I. HARIRIAN, A.M. TAMADDON, and S. MOHAMMADI SAMANI, “THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 9, no. 6, pp. 407–420, 2014, [Online]. Available: https://sid.ir/paper/318376/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops