EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MINAIYAN M.; GHANNADI A.; MOVAHEDIAN A.; RAMEZANLOU P.; OSOOLI F.S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2014 | Volume:9 | Issue:6 Page(s): 421-429

Download Full-Text

View:

328

Download:

117

Cites:

Information Journal Paper

Title

EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS

Author(s)

Keywords

PRUNUS DIVARICATA

DIABETES

HYPERLIPIDEMIA

STREPTOZOTOCIN

RATS

Abstract

PRUNUS DIVARICATA (Alloocheh) is a small tree cultivating in Iran, Middle East and central Asia. Prunus genus has many species with anti-oxidant, anti-hyperlipidemia and anti-hyperglycemia effects. In the present study the anti-diabetic and anti-hyperlipidemic effects of P. divaricata fruits were examined in normal and STREPTOZOTOCIN (STZ)-induced diabetic RATS. Both groups, control and reference RATS received normal saline and glibenclamide respectively. Test groups were treated with Prunus freeze dried juice (PFDJ, 200, 400, 800 mg/kg) and Prunus freeze dried extract (PFDE, 100, 200, 400 mg/kg) started at the 3rd day of the experiment and continued for 27 days thereafter. Weight changes of animals were checked periodically. Fasting blood glucose (FBG) level as well as serum triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol were determined. Different treatments had no significant effect on body weight increments of normal RATS, while in diabetic RATS, PFDJ (800 mg/kg) and PFDE (400 mg/kg) opposed with weight loss. In acute phase of experiment (0-8 h of 3rd day), none of tested fractions were effective in reducing FBG and serum lipids of normal RATS. During the sub-acute phase (13th and 30th days) however, the greatest test doses of PFDJ (800 mg/kg) and PFDE (400 mg/kg) induced hypoglycema. In diabetic groups, PFDJ and PFDE, at all test doses, could diminish FBG during sub-acute phase of the experiment. In addition, PFDJ and PFDE at most examined doses could diminish TG significantly and they were also effective on cholesterol derivatives in different magnitude.

Cites

No record.

References

No record.

Cite

APA: Copy

MINAIYAN, M., GHANNADI, A., MOVAHEDIAN, A., RAMEZANLOU, P., & OSOOLI, F.S.. (2014). EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(6), 421-429. SID. https://sid.ir/paper/318378/en

Vancouver: Copy

MINAIYAN M., GHANNADI A., MOVAHEDIAN A., RAMEZANLOU P., OSOOLI F.S.. EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2014;9(6):421-429. Available from: https://sid.ir/paper/318378/en

IEEE: Copy

M. MINAIYAN, A. GHANNADI, A. MOVAHEDIAN, P. RAMEZANLOU, and F.S. OSOOLI, “EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 9, no. 6, pp. 421–429, 2014, [Online]. Available: https://sid.ir/paper/318378/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops