SYNTHESIS AND CYTOTOXICITY EVALUATION OF SOME NEW 6-NITRO DERIVATIVES OF THIAZOLE-CONTAINING 4- (3H) –QUINAZOLINONE

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HOSSEINZADEH LEILA; ALIABADI ALIREZA; KALANTARI MASOOD; MOSTAFAVI ABOLFAZL; RAHMANI KHAJOUEI MARZIEH

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Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2016 | Volume:11 | Issue:3 Page(s): 210-218

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Title

SYNTHESIS AND CYTOTOXICITY EVALUATION OF SOME NEW 6-NITRO DERIVATIVES OF THIAZOLE-CONTAINING 4- (3H) –QUINAZOLINONE

Author(s)

Keywords

QUINAZOLINONE

THIAZOLE

CYTOTOXICITY

Abstract

QUINAZOLINONEs are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. THIAZOLE group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both THIAZOLE groups and quinazoline derivatives, in this study a series of QUINAZOLINONE-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (QUINAZOLINONEs and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line.K6 and C were most active compounds against MCF7 and K6 showed best CYTOTOXICITY on HT-29 cell line.

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APA: Copy

HOSSEINZADEH, LEILA, ALIABADI, ALIREZA, KALANTARI, MASOOD, MOSTAFAVI, ABOLFAZL, & RAHMANI KHAJOUEI, MARZIEH. (2016). SYNTHESIS AND CYTOTOXICITY EVALUATION OF SOME NEW 6-NITRO DERIVATIVES OF THIAZOLE-CONTAINING 4- (3H) –QUINAZOLINONE. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 11(3), 210-218. SID. https://sid.ir/paper/318429/en

Vancouver: Copy

HOSSEINZADEH LEILA, ALIABADI ALIREZA, KALANTARI MASOOD, MOSTAFAVI ABOLFAZL, RAHMANI KHAJOUEI MARZIEH. SYNTHESIS AND CYTOTOXICITY EVALUATION OF SOME NEW 6-NITRO DERIVATIVES OF THIAZOLE-CONTAINING 4- (3H) –QUINAZOLINONE. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2016;11(3):210-218. Available from: https://sid.ir/paper/318429/en

IEEE: Copy

LEILA HOSSEINZADEH, ALIREZA ALIABADI, MASOOD KALANTARI, ABOLFAZL MOSTAFAVI, and MARZIEH RAHMANI KHAJOUEI, “SYNTHESIS AND CYTOTOXICITY EVALUATION OF SOME NEW 6-NITRO DERIVATIVES OF THIAZOLE-CONTAINING 4- (3H) –QUINAZOLINONE,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 11, no. 3, pp. 210–218, 2016, [Online]. Available: https://sid.ir/paper/318429/en

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