SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME 2, 5 DISUBSTITUTED 1, 3, 4- OXADIAZOLE DERIVATIVES

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JAFARI ELHAM; MOHAMMADIAN TAHEREH; JAHANIAN NAJAFABADI ALI; HASSANZADEH FARSHID

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Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2017 | Volume:12 | Issue:4 Page(s): 330-336

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Title

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME 2, 5 DISUBSTITUTED 1, 3, 4- OXADIAZOLE DERIVATIVES

Author(s)

JAFARI ELHAM | MOHAMMADIAN TAHEREH | JAHANIAN NAJAFABADI ALI | HASSANZADEH FARSHID | Issue Writer Certificate

Keywords

OXADIAZOLE

MANDELATE

ANTIMICROBIAL

Abstract

1, 3, 4-OXADIAZOLEs are interesting compounds because of their valuable biological effects such as cytotoxic, antibacterial, antifungal, and anti-tubercular activities. Ethyl MANDELATE was treated with hydrazine hydrate to yield the corresponding acylhydrazide. Some of the 2, 5 disubstituted 1, 3, 4-OXADIAZOLE derivatives were prepared from acylhydrazide using three different procedures. In the first procedure, acylhydrazide was reacted with nitro or chloro aroyle chloride to afford a diacylhydrazide which was cyclized to 2, 5-disubstituted 1, 3, 4-OXADIAZOLE in the presence of phosphoryl chloride as dehydrating agent. In the second procedure, furan-OXADIAZOLE derivative was directly prepared from carboxylic acid and acylhydrazide in one step. In the third procedure, acyl hydrazide was condensed with 5-nitrofuraldehyde to yield 5-nitrofuran-2-yl) methylene) -2-phenyl acetohydrazide intermediate which was cyclized to form the nitrofuran-OXADIAZOLE derivative by acetic anhydride as dehydrating agent. The structures of these compounds have been elucidated by spectral IR and 1H-NMR analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Compounds F3 and F4 showed remarkable antibacterial activities against Staphylococcus aureus and Escherichia coli bacteria.

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APA: Copy

JAFARI, ELHAM, MOHAMMADIAN, TAHEREH, JAHANIAN NAJAFABADI, ALI, & HASSANZADEH, FARSHID. (2017). SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME 2, 5 DISUBSTITUTED 1, 3, 4- OXADIAZOLE DERIVATIVES. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 12(4), 330-336. SID. https://sid.ir/paper/318460/en

Vancouver: Copy

JAFARI ELHAM, MOHAMMADIAN TAHEREH, JAHANIAN NAJAFABADI ALI, HASSANZADEH FARSHID. SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME 2, 5 DISUBSTITUTED 1, 3, 4- OXADIAZOLE DERIVATIVES. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2017;12(4):330-336. Available from: https://sid.ir/paper/318460/en

IEEE: Copy

ELHAM JAFARI, TAHEREH MOHAMMADIAN, ALI JAHANIAN NAJAFABADI, and FARSHID HASSANZADEH, “SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME 2, 5 DISUBSTITUTED 1, 3, 4- OXADIAZOLE DERIVATIVES,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 12, no. 4, pp. 330–336, 2017, [Online]. Available: https://sid.ir/paper/318460/en

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