مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

ANTI-INFLAMMATORY EFFECT OF APIGENIN AND HYDROALCOHOLIC EXTRACT OF DRACOCEPHALUM KOTSCHYI ON ACETIC ACID-INDUCED COLITIS IN RATS

Pages

  322-329

Abstract

 COLITIS is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic, and environmental factors. We were interested to examine the effect of total extract from DRACOCEPHALUM KOTSCHYI (D. kotschyi) Boiss. on the experimental COLITIS. D. kotschyi HYDROALCOHOLIC EXTRACT (10, 20, and 40 mg/kg) or APIGENIN (5, 10, and 20 mg/kg) were administered orally 2 h prior to induction of COLITIS which was induced by intrarectal administration of acetic acid (4%) in rats. Prednisolone (4 m/kg) was used as the standard drug for comparison. Biochemical evaluation of inflamed colon was performed by measuring myeloperoxidase (MPO) activity. After 5 days treatment, mucosal ulceration was evaluated. Intrarectal instillation of acetic acid caused significant inflammatory reactions as indicated by macroscopic and microscopic changes. The activity of MPO increased in vehicle treated groups while recovered to normal level by pretreatment of animals with D. kotschyi extract, APIGENIN, or prednisolone. D. kotschyi and APIGENIN-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the vehicle-treated negative control group. The beneficial effect of APIGENIN was comparable with that of prednisolone. This research has shown the anti-inflammatory potential of D. kotschyiextract and APIGENIN in experimentally induced COLITIS.

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    • Cite

    APA: Copy

    SADRAEI, HASSAN, ASGHARI, GHOLAMREZA, KHANABADI, MOHAMMAD, & MINAIYAN, MOHSEN. (2017). ANTI-INFLAMMATORY EFFECT OF APIGENIN AND HYDROALCOHOLIC EXTRACT OF DRACOCEPHALUM KOTSCHYI ON ACETIC ACID-INDUCED COLITIS IN RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 12(4), 322-329. SID. https://sid.ir/paper/318462/en

    Vancouver: Copy

    SADRAEI HASSAN, ASGHARI GHOLAMREZA, KHANABADI MOHAMMAD, MINAIYAN MOHSEN. ANTI-INFLAMMATORY EFFECT OF APIGENIN AND HYDROALCOHOLIC EXTRACT OF DRACOCEPHALUM KOTSCHYI ON ACETIC ACID-INDUCED COLITIS IN RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2017;12(4):322-329. Available from: https://sid.ir/paper/318462/en

    IEEE: Copy

    HASSAN SADRAEI, GHOLAMREZA ASGHARI, MOHAMMAD KHANABADI, and MOHSEN MINAIYAN, “ANTI-INFLAMMATORY EFFECT OF APIGENIN AND HYDROALCOHOLIC EXTRACT OF DRACOCEPHALUM KOTSCHYI ON ACETIC ACID-INDUCED COLITIS IN RATS,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 12, no. 4, pp. 322–329, 2017, [Online]. Available: https://sid.ir/paper/318462/en

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