THE IMPORTANCE OF HEPATITIS B VIRUS GENOME DIVERSITY IN BASAL CORE PROMOTER REGION

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MOHAMADKHANI A.; MONTAZERI G.; POUSTCHI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2011 | Volume:3 | Issue:1 Page(s): 13-19

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Title

THE IMPORTANCE OF HEPATITIS B VIRUS GENOME DIVERSITY IN BASAL CORE PROMOTER REGION

Author(s)

MOHAMADKHANI A. | MONTAZERI G. | POUSTCHI H. | Issue Writer Certificate

Keywords

HEPATITIS B VIRUS MUTATION

BASAL CORE PROMOTER

HBV RNA

PROTEIN X

Abstract

Hepadnaviruses employ an unusual strategy for the production of enormous number of virions during replication which makes rapid and substantial genetic sequence changes and alterations. The pathogenesis and clearance of hepatitis B virus (HBV) infection are engaged by the selection and expression of viral mutants during virus-host interactions. Mutations in regulatory regions such as the BASAL CORE PROMOTER (BCP) which is thought to be related to lower production of hepatitis B "e" antigen (HBeAg) directly affects the clinical presentation of liver disease. However, the molecular structure of these mutations in chronic carriers has not been adequately evaluated. In this review we evaluate the molecular aspect and pathologic basis of BASAL CORE PROMOTER mutations.

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APA: Copy

MOHAMADKHANI, A., MONTAZERI, G., & POUSTCHI, H.. (2011). THE IMPORTANCE OF HEPATITIS B VIRUS GENOME DIVERSITY IN BASAL CORE PROMOTER REGION. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 3(1), 13-19. SID. https://sid.ir/paper/319052/en

Vancouver: Copy

MOHAMADKHANI A., MONTAZERI G., POUSTCHI H.. THE IMPORTANCE OF HEPATITIS B VIRUS GENOME DIVERSITY IN BASAL CORE PROMOTER REGION. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2011;3(1):13-19. Available from: https://sid.ir/paper/319052/en

IEEE: Copy

A. MOHAMADKHANI, G. MONTAZERI, and H. POUSTCHI, “THE IMPORTANCE OF HEPATITIS B VIRUS GENOME DIVERSITY IN BASAL CORE PROMOTER REGION,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 3, no. 1, pp. 13–19, 2011, [Online]. Available: https://sid.ir/paper/319052/en

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