A COMPARISON BETWEEN MODERATE- AND HIGH-DOSE FURAZOLIDONE IN TRIPLE REGIMENS FOR HELICOBACTERPYLORI ERADICATION IN IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINI VAHIDEH; MOKHTARE MARJAN; GHOLAMI MOHSEN; TAGHVAEI TARANG; MALEKI IRADJ; VALIZADEH MOHAMMAD; BARI ZOHREH; FAKHERI HAFEZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2014 | Volume:6 | Issue:4 Page(s): 195-202

Download Full-Text

View:

256

Download:

120

Cites:

Information Journal Paper

Title

A COMPARISON BETWEEN MODERATE- AND HIGH-DOSE FURAZOLIDONE IN TRIPLE REGIMENS FOR HELICOBACTERPYLORI ERADICATION IN IRAN

Author(s)

Keywords

HELICOBACTER PYLORI

ERADICATION

FURAZOLIDONE

Abstract

BACKGROUND: FURAZOLIDONE has been used as an alternative for clarithromycin or metronidazole in Helicobacterpylori (H.pylori) ERADICATION regimens. In Iran, 14-day FURAZOLIDONE-containing quadruple regimens have shown promising ERADICATION rates, but short-course, low dose therapies are always attractive. Therefore, we designed a study to compare the efficacy of two 10-day triple regimens containing moderate and high dose FURAZOLIDONE for H.pylori ERADICATION.METHODS Two hundred and ten patients with peptic ulcer disease who were naïve to H.pylori treatment were included. They were randomized into 2 groups: 105 patients received omeprazole 20mg, amoxicillin 1000mg, and FURAZOLIDONE 200mg (OAF-400), all twice a day for ten days.And the remaining 105 patients received omeprazole 20mg twice a day, amoxicillin 1000mg twice a day and FURAZOLIDONE 200mg three times a day for ten days (OAF-600). Urease breath test was performed 8 weeks after the treatment to confirm H. pylori ERADICATION.RESULTS the intention-to-treat ERADICATION rate was 76.19% in group OAF-400 and 80.95% in group OAF-600 (p=0.38). Per protocol ERADICATION rates were 81.63% and 89.47%, respectively (p=0.11).Severe adverse effects were reported by 8.6% of the patients in group OAF-400 and 5.7% of the patient in group OAF-600 (p=0.1). However, the total side effects (including mild, moderate, and severe ones) were significantly more prevalent in the OAF-600 group (p=0.001).CONCLUSION: None of our triple FURAZOLIDONE-based regimens (moderate- and high-dose) could achieve the standard ERADICATION rate, and therefore, cannot be considered as a suitable option for first-line treatment.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINI, VAHIDEH, MOKHTARE, MARJAN, GHOLAMI, MOHSEN, TAGHVAEI, TARANG, MALEKI, IRADJ, VALIZADEH, MOHAMMAD, BARI, ZOHREH, & FAKHERI, HAFEZ. (2014). A COMPARISON BETWEEN MODERATE- AND HIGH-DOSE FURAZOLIDONE IN TRIPLE REGIMENS FOR HELICOBACTERPYLORI ERADICATION IN IRAN. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 6(4), 195-202. SID. https://sid.ir/paper/319097/en

Vancouver: Copy

HOSSEINI VAHIDEH, MOKHTARE MARJAN, GHOLAMI MOHSEN, TAGHVAEI TARANG, MALEKI IRADJ, VALIZADEH MOHAMMAD, BARI ZOHREH, FAKHERI HAFEZ. A COMPARISON BETWEEN MODERATE- AND HIGH-DOSE FURAZOLIDONE IN TRIPLE REGIMENS FOR HELICOBACTERPYLORI ERADICATION IN IRAN. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2014;6(4):195-202. Available from: https://sid.ir/paper/319097/en

IEEE: Copy

VAHIDEH HOSSEINI, MARJAN MOKHTARE, MOHSEN GHOLAMI, TARANG TAGHVAEI, IRADJ MALEKI, MOHAMMAD VALIZADEH, ZOHREH BARI, and HAFEZ FAKHERI, “A COMPARISON BETWEEN MODERATE- AND HIGH-DOSE FURAZOLIDONE IN TRIPLE REGIMENS FOR HELICOBACTERPYLORI ERADICATION IN IRAN,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 6, no. 4, pp. 195–202, 2014, [Online]. Available: https://sid.ir/paper/319097/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops