INVERSE ASSOCIATION OF PLASMA LEVEL OF GLUTATHIONE PEROXIDASE WITH LIVER FIBROSIS IN CHRONIC HEPATITIS B: POTENTIAL ROLE OF IRON

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MOOSSAVI SHIRIN; BESHARAT SIMA; SHARAFKHAH MARYAM; GHANBARI REZA; SHARIFI AMROLLAH; REZANEJAD PARISA; POURSHAMS AKRAM; POUSTCHI HOSSEIN; MOHAMADKHANI ASHRAF

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Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2016 | Volume:8 | Issue:2 Page(s): 122-130

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Title

INVERSE ASSOCIATION OF PLASMA LEVEL OF GLUTATHIONE PEROXIDASE WITH LIVER FIBROSIS IN CHRONIC HEPATITIS B: POTENTIAL ROLE OF IRON

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Keywords

GLUTATHIONE PEROXIDASE (GPX)

HEPATITIS B

IRON

LIVER STIFFNESS

HBV DNA

Abstract

BACKGROUND: Oxidative stress has a major pathogenic role for liver damage following chronic HEPATITIS B. Glutathione peroxidase (Gpx) is necessary in oxidative state mechanism that is generally down-regulated by HEPATITIS B virus (HBV) infection. On the other hand, disorders of IRON homeostasis have been found out in HBV infected patients. Therefore, the objective of this study was to assess the interplay of Gpx and serum IRON on clinical and virological features of patients with chronic HBV infection.METHODS One hundred and fifty adult, treatment-naïve, patients with chronic HEPATITIS B were randomly designated from an ongoing cohort of patients with HBV.Plasma Gpx1 concentration and HBV DNA quantity were measured. LIVER STIFFNESS was measured by transient elastography.RESULTS: Serum IRON had a positive association with HBV DNA count in the total population.Serum IRON was not associated with LIVER STIFFNESS. However, HBV DNA was significantly associated with LIVER STIFFNESS only in male patients. Serum Gpx was inversely associated with LIVER STIFFNESS. Serum IRON and Gpx had indirect effects on LIVER STIFFNESS via HBV DNA count. We observed dissimilar effects of serum IRON on HBV DNA and Gpx on LIVER STIFFNESS in male and female patients.CONCLUSION: We identified interplay of serum IRON and Gpx1 in relation to level of liver fibrosis in patients with chronic HEPATITIS B. Our results propose that oxidative stress and serum IRON are differentially implicated in the progression of chronic HEPATITIS B in male and female patients.

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APA: Copy

MOOSSAVI, SHIRIN, BESHARAT, SIMA, SHARAFKHAH, MARYAM, GHANBARI, REZA, SHARIFI, AMROLLAH, REZANEJAD, PARISA, POURSHAMS, AKRAM, POUSTCHI, HOSSEIN, & MOHAMADKHANI, ASHRAF. (2016). INVERSE ASSOCIATION OF PLASMA LEVEL OF GLUTATHIONE PEROXIDASE WITH LIVER FIBROSIS IN CHRONIC HEPATITIS B: POTENTIAL ROLE OF IRON. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(2), 122-130. SID. https://sid.ir/paper/319126/en

Vancouver: Copy

MOOSSAVI SHIRIN, BESHARAT SIMA, SHARAFKHAH MARYAM, GHANBARI REZA, SHARIFI AMROLLAH, REZANEJAD PARISA, POURSHAMS AKRAM, POUSTCHI HOSSEIN, MOHAMADKHANI ASHRAF. INVERSE ASSOCIATION OF PLASMA LEVEL OF GLUTATHIONE PEROXIDASE WITH LIVER FIBROSIS IN CHRONIC HEPATITIS B: POTENTIAL ROLE OF IRON. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2016;8(2):122-130. Available from: https://sid.ir/paper/319126/en

IEEE: Copy

SHIRIN MOOSSAVI, SIMA BESHARAT, MARYAM SHARAFKHAH, REZA GHANBARI, AMROLLAH SHARIFI, PARISA REZANEJAD, AKRAM POURSHAMS, HOSSEIN POUSTCHI, and ASHRAF MOHAMADKHANI, “INVERSE ASSOCIATION OF PLASMA LEVEL OF GLUTATHIONE PEROXIDASE WITH LIVER FIBROSIS IN CHRONIC HEPATITIS B: POTENTIAL ROLE OF IRON,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 8, no. 2, pp. 122–130, 2016, [Online]. Available: https://sid.ir/paper/319126/en

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