THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL

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SHAFAGHI AFSHIN; POURKAZEMI AYDIN; KHOSRAVANI MOHSEN; FAKHRIEH ASL SABA; AMIR MAAFI ALIREZA; ATRKAR ROSHAN ZAHRA; ABASPOUR RAHIMABAD JAFAR

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Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2016 | Volume:8 | Issue:3 Page(s): 201-210

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Title

THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL

Author(s)

Keywords

ERADICATION

H. PYLORI

PROBIOTIC

PREBIOTIC

SYNBIOTIC

QUADRUPLE THERAPY 201

Abstract

BACKGROUND Standard anti-Helicobacter pylori (H. pylori) treatment fails in the ERADICATION of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that PROBIOTIC supplementations with or without PREBIOTIC may improve the ERADICATION rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of PROBIOTIC with PREBIOTIC supplementation on the ERADICATION rate and side effects of antiH. pylori quadruple therapy.METHODS 76 patients with a positive biopsy specimen forH. pylori were enrolled.They were randomized to receive quadruple therapy of bismuth, clarithromycin, amoxicillin, and omeprazole for 14 days and also the SYNBIOTIC or the placebo.We asked them to answer study questionnaires at the beginning and during the treatment. Finally, urea breath test was done 8 weeks after the treatment.RESULTS The ERADICATION rate was significantly better in the SYNBIOTIC group by intention-to-treat analysis (p<0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, constipation, and taste abnormality were similar in both groups but anorexia was significantly better in the SYNBIOTIC group (p<0.05).CONCLUSION The ERADICATION rate was significantly better in the SYNBIOTIC group by intention-to-treat analysis (p<0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, ut could improve the ERADICATION by augmenting the treatment tolerance and compliance.

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APA: Copy

SHAFAGHI, AFSHIN, POURKAZEMI, AYDIN, KHOSRAVANI, MOHSEN, FAKHRIEH ASL, SABA, AMIR MAAFI, ALIREZA, ATRKAR ROSHAN, ZAHRA, & ABASPOUR RAHIMABAD, JAFAR. (2016). THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(3), 201-210. SID. https://sid.ir/paper/319139/en

Vancouver: Copy

SHAFAGHI AFSHIN, POURKAZEMI AYDIN, KHOSRAVANI MOHSEN, FAKHRIEH ASL SABA, AMIR MAAFI ALIREZA, ATRKAR ROSHAN ZAHRA, ABASPOUR RAHIMABAD JAFAR. THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2016;8(3):201-210. Available from: https://sid.ir/paper/319139/en

IEEE: Copy

AFSHIN SHAFAGHI, AYDIN POURKAZEMI, MOHSEN KHOSRAVANI, SABA FAKHRIEH ASL, ALIREZA AMIR MAAFI, ZAHRA ATRKAR ROSHAN, and JAFAR ABASPOUR RAHIMABAD, “THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 8, no. 3, pp. 201–210, 2016, [Online]. Available: https://sid.ir/paper/319139/en

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