ABERRANT DNA METHYLATION OF TWO TUMOR SUPPRESSOR GENES, P14ARF AND P15INK4B, AFTER CHRONIC OCCUPATIONAL EXPOSURE TO LOW LEVEL OF BENZENE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAMEBOZORGI IRAJ; MAJIDIZADEH TAYEBEH; POURYAGHOUB GHOLAMREZA; MAHJOUBI FROUZANDEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE Year:2018 | Volume:9 | Issue:3 Page(s): 145-151

Download Full-Text

View:

241

Download:

118

Cites:

Information Journal Paper

Title

ABERRANT DNA METHYLATION OF TWO TUMOR SUPPRESSOR GENES, P14ARF AND P15INK4B, AFTER CHRONIC OCCUPATIONAL EXPOSURE TO LOW LEVEL OF BENZENE

Author(s)

JAMEBOZORGI IRAJ | MAJIDIZADEH TAYEBEH | POURYAGHOUB GHOLAMREZA | MAHJOUBI FROUZANDEH | Issue Writer Certificate

Keywords

BENZENE

DNA METHYLATION

GENES

TUMOR SUPPRESSOR

TUMOR SUPPRESSOR PROTEIN P14ARF

CYCLIN-DEPENDENT KINASE INHIBITOR P15

NEOPLASMS

Abstract

Background: Exposure to BENZENE would be associated with many diseases including leukemia. Epigenetic alterations seem to be among the main mechanisms involved.Objective: To determine if chronic occupational exposure to low level of BENZENE would be associated with DNA METHYLATION.Methods: Global DNA METHYLATION and promoter-specific methylation of the two TUMOR SUPPRESSOR GENES, p14ARF and p15INK4b, were assessed employing methylation-specific PCR using the DNA extracted from 40 petrochemical workers exposed to ambient BENZENE levels of<1 ppm, and 31 office workers not exposed to BENZENE or its derivatives.Results: While an increase in global DNA METHYLATION of 5% in p14ARF (p=0.501) and 28% in p15INK4b (p=0.02) GENES was observed in the exposed group, no hyper methylation in either of the studied GENES was observed in the unexposed group. No significant association was found between the frequency of aberrant methylation and either of age, work experience, and smoking habit in the exposed group.Conclusion: Chronic occupational exposure to lower than the permissible exposure limit of BENZENE may still result in DNA METHYLATION of TUMOR SUPPRESSOR GENES that may ultimately lead to development of cancer.

Cites

No record.

References

No record.

Cite

APA: Copy

JAMEBOZORGI, IRAJ, MAJIDIZADEH, TAYEBEH, POURYAGHOUB, GHOLAMREZA, & MAHJOUBI, FROUZANDEH. (2018). ABERRANT DNA METHYLATION OF TWO TUMOR SUPPRESSOR GENES, P1^4ARF AND P15^INK4B, AFTER CHRONIC OCCUPATIONAL EXPOSURE TO LOW LEVEL OF BENZENE. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 9(3), 145-151. SID. https://sid.ir/paper/320354/en

Vancouver: Copy

JAMEBOZORGI IRAJ, MAJIDIZADEH TAYEBEH, POURYAGHOUB GHOLAMREZA, MAHJOUBI FROUZANDEH. ABERRANT DNA METHYLATION OF TWO TUMOR SUPPRESSOR GENES, P1^4ARF AND P15^INK4B, AFTER CHRONIC OCCUPATIONAL EXPOSURE TO LOW LEVEL OF BENZENE. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE[Internet]. 2018;9(3):145-151. Available from: https://sid.ir/paper/320354/en

IEEE: Copy

IRAJ JAMEBOZORGI, TAYEBEH MAJIDIZADEH, GHOLAMREZA POURYAGHOUB, and FROUZANDEH MAHJOUBI, “ABERRANT DNA METHYLATION OF TWO TUMOR SUPPRESSOR GENES, P1^4ARF AND P15^INK4B, AFTER CHRONIC OCCUPATIONAL EXPOSURE TO LOW LEVEL OF BENZENE,” INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 9, no. 3, pp. 145–151, 2018, [Online]. Available: https://sid.ir/paper/320354/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops