Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with β-Thalassemia major

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Shanaki Mehrnoosh; EHTERAM HASSAN; NASIRI HAJAR; AZAD MEHDI; KOUHKAN FATEMEH; PAKZAD REZA; MOBARRA NASER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY Year:2016 | Volume:6 | Issue:4 Page(s): 248-259

Download Full-Text

View:

202

Download:

241

Cites:

Information Journal Paper

Title

Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with β-Thalassemia major

Author(s)

Keywords

Beta-thalassemia major

kidney

live

Inflammatory

Oxidative stress

Abstract

Background: Thalassemias are the most common inherited blood disorders caused by some mutations which can reduce the synthesis of globin chains. Iron overload and its organ deposition are responsible for functional abnormalities and tissue injury in patients who affected by β-thalassemia major. The aim of this case-control study was evaluation of hematological parameters, Oxidative stress and some serum liver and kidney risk factors which play crucial role for early prediction and prevention of patients to end-stage tissue failure and mortality. Materials and Methods: Present study consisted of Fifty young adult subjects with β-thalassemia major (β-TM) (aged<18 years) and same number age and sex-matched healthy subjects as control group. Hematological and biochemical laboratory parameters included Urea, Creatinine, Uric Acid, Aspartate Aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP) (pars azmoon kit), Oxidative stress biomarker PAB, giving a redox index (chemically), and serum high-sensitivity C-reactive protein (hs-CRP) were evaluated. Results: Urea, Creatinine and Uric Acid were significantly decreased in patients group (P<0. 001); in spite of, serum ferritin, liver biomarkers AST, ALT, ALP and risk factor biomarker PAB were statistically increased in patients versus control group(P<0. 001), whereas hs-CRP(P>0. 05) was not significantly difference in study groups. Exception hs-CRP and PAB (P>0. 05), liver risk factors had a positive correlation with ferritin and serum Urea, Creatinine and Uric Acid tests had negative meaningful with hematological parameters (P<0. 001). Likewise, PAB with AST showed a positive correlation (P<0. 001) and irreversibly with urea and creatinine (P<0. 001). We did not find a slight correlation between hs-CRP in the company to hematological and biochemical laboratory finding (P>0. 05). Conclusion: Higher level of risk factors PAB values and key liver enzyme profiles are able to involve in the prognostic pathological consequences in patients with β-thalassemia major. Even so, they contribute toward the gradual development of tissue injuries.

Cites

No record.

References

No record.

Cite

APA: Copy

Shanaki, Mehrnoosh, EHTERAM, HASSAN, NASIRI, HAJAR, AZAD, MEHDI, KOUHKAN, FATEMEH, PAKZAD, REZA, & MOBARRA, NASER. (2016). Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with β-Thalassemia major. IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY, 6(4), 248-259. SID. https://sid.ir/paper/320658/en

Vancouver: Copy

Shanaki Mehrnoosh, EHTERAM HASSAN, NASIRI HAJAR, AZAD MEHDI, KOUHKAN FATEMEH, PAKZAD REZA, MOBARRA NASER. Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with β-Thalassemia major. IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY[Internet]. 2016;6(4):248-259. Available from: https://sid.ir/paper/320658/en

IEEE: Copy

Mehrnoosh Shanaki, HASSAN EHTERAM, HAJAR NASIRI, MEHDI AZAD, FATEMEH KOUHKAN, REZA PAKZAD, and NASER MOBARRA, “Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with β-Thalassemia major,” IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol. 6, no. 4, pp. 248–259, 2016, [Online]. Available: https://sid.ir/paper/320658/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops