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Information Journal Paper

Title

Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency

Pages

  157-165

Abstract

 Background: Sodium Bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematologic factors and their side effects in patients with Hemolysis caused by G6PD deficiency. Materials and Methods: In this clinical trial study, 79 patients with Favism randomly put into two treatment groups, Sodium Bicarbonate and sodium chloride fluid therapy. During treatment, patients received blood based on hemoglobin (Hb). Duration of hospitalization, times of Blood transfusion, received blood volume, duration of cleaning UA of Hb, Hb, urine pH and granular casts in UA were evaluated. Results: The mean age of patients was 51. 22 ± 37. 86 months and there were 58 males and 21 females. Only duration of hospitalization and urine pH statistically showed a significant difference between two treatment groups (P=0. 036 and P> 0. 01, respectively), and other factors were statistically almost identical. Conclusion: The efficiency of sodium chloride was more than Sodium Bicarbonate in reducing the duration of hospitalization and the small clinical difference between received blood volumes, hemoglobin changes and duration of removing hemoglobin in UA, suggest, properly, sodium chloride can be more effective on improvement of Hemolysis. Lack of side effects such as metabolic acidosis, heart damage and kidney failure in children can be due to controlled injection method, the concentration of soluble drugs and small size of studied population.

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    APA: Copy

    Beigom Mirbehbahani, Narges, Salami Khanshan, Aysan, SAFAIAN, BARANAK, MOHAMMADIAN, SAKINEH, BEHNAMPOUR, NASSER, Ariannejad, Safa, Masoomnia, Ali Reza, Malekmarzban, Azin, & Rashidbaghan, Azam. (2016). Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency. IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY, 6(3), 157-165. SID. https://sid.ir/paper/320683/en

    Vancouver: Copy

    Beigom Mirbehbahani Narges, Salami Khanshan Aysan, SAFAIAN BARANAK, MOHAMMADIAN SAKINEH, BEHNAMPOUR NASSER, Ariannejad Safa, Masoomnia Ali Reza, Malekmarzban Azin, Rashidbaghan Azam. Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency. IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY[Internet]. 2016;6(3):157-165. Available from: https://sid.ir/paper/320683/en

    IEEE: Copy

    Narges Beigom Mirbehbahani, Aysan Salami Khanshan, BARANAK SAFAIAN, SAKINEH MOHAMMADIAN, NASSER BEHNAMPOUR, Safa Ariannejad, Ali Reza Masoomnia, Azin Malekmarzban, and Azam Rashidbaghan, “Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency,” IRANIAN JOURNAL OF PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol. 6, no. 3, pp. 157–165, 2016, [Online]. Available: https://sid.ir/paper/320683/en

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