ARTIFICIAL ENDOMETRIAL PREPARATION FOR FROZEN-THAWED EMBRYO TRANSFER WITH OR WITHOUT PRETREATMENT WITH DEPOT GONADOTROPIN RELEASING HORMONE AGONIST IN WOMEN WITH REGULAR MENSES

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AZIMI NEKOO ELHAM; CHAMANI MARYAM; SHAHROKH TEHRANI ENSIEH; HOSSEIN RASHIDI BATOOL; DAVARI TANHA FATEMEH; KALANTARI VAHID

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Journal: JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH Year:2015 | Volume:9 | Issue:1 Page(s): 1-4

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Title

ARTIFICIAL ENDOMETRIAL PREPARATION FOR FROZEN-THAWED EMBRYO TRANSFER WITH OR WITHOUT PRETREATMENT WITH DEPOT GONADOTROPIN RELEASING HORMONE AGONIST IN WOMEN WITH REGULAR MENSES

Author(s)

Keywords

FROZEN-THAWED EMBRYO TRANSFER

GNRH AGONIST

ARTIFICIAL CYCLE

ENDOMETRIAL PREPARATION

PREGNANCY OUTCOME

Abstract

Objective: To investigate the reproductive outcome of artificial ENDOMETRIAL PREPARATION with exogenous steroids for FROZEN-THAWED EMBRYO TRANSFER with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses.Materials and methods: This is a prospective randomized clinical trial conducted in two ART centers on 176 women undergoing FROZEN-THAWED EMBRYO TRANSFER. All patients received oral estradiol valerate 4 mg daily from day 2 to day 5 and 6 mg per day from day 6 to the day of the pregnancy test. In day 13 of cycle, an ultrasound examination was performed. After ultrasound confirmation of endometrial thickness (³8 mm) and no ovarian activity, progesterone in cyclogest supp (800 mg daily) was added. The dose of estradiol would be increased to 8 mg per day if the endometrial thickness was less than 8mm. Two or 3 embryos were transferred via transcervical route 48 hours after the beginning of progesterone administration. In group A (93 patients), Difereline (3.75 mg Im), as a depot GNRH AGONIST was administered in the midluteal phase (day 21) of previous cycle. In the other group B (n=83) steroid supplementation was commenced without prior pituitary suppression. Chemical and clinical pregnancy rates were compared in two groups.Results: No significant differences were seen between two groups in terms of chemical pregnancy and clinical pregnancy rates.Conclusion: The findings support the artificial protocol without any pretreatment suppressive drugs to reduce the adverse side effects of GNRH AGONISTs also to minimize the costs.

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APA: Copy

AZIMI NEKOO, ELHAM, CHAMANI, MARYAM, SHAHROKH TEHRANI, ENSIEH, HOSSEIN RASHIDI, BATOOL, DAVARI TANHA, FATEMEH, & KALANTARI, VAHID. (2015). ARTIFICIAL ENDOMETRIAL PREPARATION FOR FROZEN-THAWED EMBRYO TRANSFER WITH OR WITHOUT PRETREATMENT WITH DEPOT GONADOTROPIN RELEASING HORMONE AGONIST IN WOMEN WITH REGULAR MENSES. JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH, 9(1), 1-4. SID. https://sid.ir/paper/320900/en

Vancouver: Copy

AZIMI NEKOO ELHAM, CHAMANI MARYAM, SHAHROKH TEHRANI ENSIEH, HOSSEIN RASHIDI BATOOL, DAVARI TANHA FATEMEH, KALANTARI VAHID. ARTIFICIAL ENDOMETRIAL PREPARATION FOR FROZEN-THAWED EMBRYO TRANSFER WITH OR WITHOUT PRETREATMENT WITH DEPOT GONADOTROPIN RELEASING HORMONE AGONIST IN WOMEN WITH REGULAR MENSES. JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH[Internet]. 2015;9(1):1-4. Available from: https://sid.ir/paper/320900/en

IEEE: Copy

ELHAM AZIMI NEKOO, MARYAM CHAMANI, ENSIEH SHAHROKH TEHRANI, BATOOL HOSSEIN RASHIDI, FATEMEH DAVARI TANHA, and VAHID KALANTARI, “ARTIFICIAL ENDOMETRIAL PREPARATION FOR FROZEN-THAWED EMBRYO TRANSFER WITH OR WITHOUT PRETREATMENT WITH DEPOT GONADOTROPIN RELEASING HORMONE AGONIST IN WOMEN WITH REGULAR MENSES,” JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH, vol. 9, no. 1, pp. 1–4, 2015, [Online]. Available: https://sid.ir/paper/320900/en

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