ERADICATION OF ESTABLISHED MURINE SKIN TUMORS BY CYCLIC CHEMOIMMUNOTHERAPY WITH CYCLOPHOSPHAMIDE AND EFFECTOR T CELLS

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MATSUYAMA KOKI; TANAKA HIROSHI; OTA TAKESHI; BABA JUNKO; MIYABAYASHI TAKAO; WATANABE SATOSHI; KAGAMU HIROSHI; NARITA ICHIEI; NAKATA KOH; YOSHIZAWA HIROHISA

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Journal: MIDDLE EAST JOURNAL OF CANCER Year:2011 | Volume:2 | Issue:1 Page(s): 9-18

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Title

ERADICATION OF ESTABLISHED MURINE SKIN TUMORS BY CYCLIC CHEMOIMMUNOTHERAPY WITH CYCLOPHOSPHAMIDE AND EFFECTOR T CELLS

Author(s)

Keywords

TUMOR IMMUNOTHERAPY

CYCLOPHOSPHAMIDE

REGULATORY T CELL

Abstract

Background: Nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting REGULATORY T CELLs in the host.However, its efficacy is transient. Here, we aim to investigate whether cyclic chemoimmunotherapy has therapeutic efficacy against cancer.Methods: We examined the efficacy of cyclic chemoimmunotherapy with CYCLOPHOSPHAMIDE and adoptively transferred effector T cells against 5-day, established MCA205 murine skin sarcomas.Results: CYCLOPHOSPHAMIDE administration followed by adoptive immunotherapy augmented the trafficking of effector T cells into established tumors. Further, multiple CYCLOPHOSPHAMIDE administrations helped effector T cells to persist at the sites.Chemoimmunotherapy achieved complete tumor regression even with the transfer of a limited number of effector T cells (5x106).Conclusion: Cyclic chemoimmunotherapy, which maintains adoptively transferred T cells by impairing REGULATORY T CELLs, is a potentially suitable treatment for established tumors.

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APA: Copy

MATSUYAMA, KOKI, TANAKA, HIROSHI, OTA, TAKESHI, BABA, JUNKO, MIYABAYASHI, TAKAO, WATANABE, SATOSHI, KAGAMU, HIROSHI, NARITA, ICHIEI, NAKATA, KOH, & YOSHIZAWA, HIROHISA. (2011). ERADICATION OF ESTABLISHED MURINE SKIN TUMORS BY CYCLIC CHEMOIMMUNOTHERAPY WITH CYCLOPHOSPHAMIDE AND EFFECTOR T CELLS. MIDDLE EAST JOURNAL OF CANCER, 2(1), 9-18. SID. https://sid.ir/paper/321004/en

Vancouver: Copy

MATSUYAMA KOKI, TANAKA HIROSHI, OTA TAKESHI, BABA JUNKO, MIYABAYASHI TAKAO, WATANABE SATOSHI, KAGAMU HIROSHI, NARITA ICHIEI, NAKATA KOH, YOSHIZAWA HIROHISA. ERADICATION OF ESTABLISHED MURINE SKIN TUMORS BY CYCLIC CHEMOIMMUNOTHERAPY WITH CYCLOPHOSPHAMIDE AND EFFECTOR T CELLS. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2011;2(1):9-18. Available from: https://sid.ir/paper/321004/en

IEEE: Copy

KOKI MATSUYAMA, HIROSHI TANAKA, TAKESHI OTA, JUNKO BABA, TAKAO MIYABAYASHI, SATOSHI WATANABE, HIROSHI KAGAMU, ICHIEI NARITA, KOH NAKATA, and HIROHISA YOSHIZAWA, “ERADICATION OF ESTABLISHED MURINE SKIN TUMORS BY CYCLIC CHEMOIMMUNOTHERAPY WITH CYCLOPHOSPHAMIDE AND EFFECTOR T CELLS,” MIDDLE EAST JOURNAL OF CANCER, vol. 2, no. 1, pp. 9–18, 2011, [Online]. Available: https://sid.ir/paper/321004/en

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