مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

INCREASED IL-17 AND IL-6 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS: IMPLICATION FOR A ROBUST PROINFLAMMATORY RESPONSE IN EARLY STAGES OF BREAST CANCER

Pages

  19-26

Abstract

 Background: Several recent studies demonstrated that TRANSFORMING GROWTH FACTOR BETA (TGF-b), by stimulating T regulatory cells, and interleukins 6 and 17 (IL-6, IL-17), by inducing inflammatory reactions, may be critical factors in cancer pathogenesis.Methods: We used quantitative real-time polymerase chain reaction assays to quantify the expression of IL-17, IL-6 and TGF-b mRNA in peripheral blood mononuclear cells and lymphocytes from draining lymph nodes of 60 women with BREAST CANCER. The results were compared according to the patients’ clinical or pathological status.Results: Higher amounts of IL-17 and IL-6 mRNA, but not TGF-b transcripts, were found in patients compared to controls. There were no significant differences between patients with negative or positive nodes or with different histological grades or stages of disease.Conclusion: Most women in this analysis had stage I or II disease. We thus conclude that IL-17, a prominent proinflammatory cytokine, may play an important role in recruiting and infiltrating antitumor immune responses in early stages of BREAST CANCER.

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    APA: Copy

    JABERIPOUR, MANSOOREH, BAHARLOU, RASOUL, HOSSEINI, AHMAD, TALEI, ABDOLRASOUL, RAZMKHAH, MAHBOOBEH, & GHADERI, ABBAS. (2011). INCREASED IL-17 AND IL-6 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS: IMPLICATION FOR A ROBUST PROINFLAMMATORY RESPONSE IN EARLY STAGES OF BREAST CANCER. MIDDLE EAST JOURNAL OF CANCER, 2(1), 19-26. SID. https://sid.ir/paper/321010/en

    Vancouver: Copy

    JABERIPOUR MANSOOREH, BAHARLOU RASOUL, HOSSEINI AHMAD, TALEI ABDOLRASOUL, RAZMKHAH MAHBOOBEH, GHADERI ABBAS. INCREASED IL-17 AND IL-6 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS: IMPLICATION FOR A ROBUST PROINFLAMMATORY RESPONSE IN EARLY STAGES OF BREAST CANCER. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2011;2(1):19-26. Available from: https://sid.ir/paper/321010/en

    IEEE: Copy

    MANSOOREH JABERIPOUR, RASOUL BAHARLOU, AHMAD HOSSEINI, ABDOLRASOUL TALEI, MAHBOOBEH RAZMKHAH, and ABBAS GHADERI, “INCREASED IL-17 AND IL-6 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS: IMPLICATION FOR A ROBUST PROINFLAMMATORY RESPONSE IN EARLY STAGES OF BREAST CANCER,” MIDDLE EAST JOURNAL OF CANCER, vol. 2, no. 1, pp. 19–26, 2011, [Online]. Available: https://sid.ir/paper/321010/en

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