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Information Journal Paper

Title

CLINICOPATHOLOGIC FEATURES AND SURVIVAL OF BREAST CANCER SUBTYPES IN NORTHEAST IRAN

Pages

  27-33

Abstract

 Background: Breast cancer can be categorized into different histopathological subtypes based on gene expression profiles. This study aims to evaluate the clinic opathological features and overall SURVIVAL of various subtypes of breast cancer to assist diagnosis and guide treatment.Methods: The clinic opathologic features of 1095 patients with breast cancer diagnosed over a 10–year period between 2001 and 2011 were analyzed. The Kaplan–Meier method was used to analyze disease-free SURVIVAL and overall SURVIVAL. Calculation of the hazard ratio was conducted by multivariate Cox regression.Results: According to the clinic opathologic characteristics of 1095 cases, there were 42% luminal A subtype, 19.2% luminal B, 23% triple negative, and 15% HER2+. The lowest (46.88 ± 12.59 years) and highest (50.54 ± 12.32 years) mean ages were in the triple negative and HER2+groups, respectively. There was a significant correlation between histology subtype and age, BMI, lymph node, type of surgery, and stage of disease. There was significantly shorter overall SURVIVAL and disease free SURVIVAL in HER2+breast cancer patients (P<0.001). Multivariate analysis showed that age had the highest hazard ratio of 2.481 (95% Confidence Interval: 1.375-4.477).Conclusion: The results of this study showed the importance of clinicopathological studies of molecular types which help early diagnosis and identification of the best strategy to treat breast cancer.

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    APA: Copy

    SHAHIDSALES, SOODABEH, JOUDI, MONA, Mirsadraee, Marjaneh, AVAN, AMIR, AHMADI SIMAB, SAEIDEH, & GHAVAMNASIRI, MOHAMMAD REZA. (2018). CLINICOPATHOLOGIC FEATURES AND SURVIVAL OF BREAST CANCER SUBTYPES IN NORTHEAST IRAN. MIDDLE EAST JOURNAL OF CANCER, 9(1), 27-33. SID. https://sid.ir/paper/321192/en

    Vancouver: Copy

    SHAHIDSALES SOODABEH, JOUDI MONA, Mirsadraee Marjaneh, AVAN AMIR, AHMADI SIMAB SAEIDEH, GHAVAMNASIRI MOHAMMAD REZA. CLINICOPATHOLOGIC FEATURES AND SURVIVAL OF BREAST CANCER SUBTYPES IN NORTHEAST IRAN. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(1):27-33. Available from: https://sid.ir/paper/321192/en

    IEEE: Copy

    SOODABEH SHAHIDSALES, MONA JOUDI, Marjaneh Mirsadraee, AMIR AVAN, SAEIDEH AHMADI SIMAB, and MOHAMMAD REZA GHAVAMNASIRI, “CLINICOPATHOLOGIC FEATURES AND SURVIVAL OF BREAST CANCER SUBTYPES IN NORTHEAST IRAN,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 1, pp. 27–33, 2018, [Online]. Available: https://sid.ir/paper/321192/en

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