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Information Journal Paper

Title

PTEN and p53 Gene Expressions inBreast Cancer Specimens and their Clinicopathological Significance

Pages

  105-111

Keywords

P53 

Abstract

 Background: Breast cancer is the second leading cause of cancer death after lungcancer. Discovering molecular biomarkers is necessary for disease management thatincludes prognosis prediction and preventive treatment. The aim of this study is toevaluate the expression value of P53 and PTEN as molecular biomarkers of Breast cancerand their relation with clinicopathological characteristics. Methods: In this study, 100 Breast cancer and 20 normal samples were subjectedto investigation. Total RNA was isolated and we measured RNA expression by realtimeRT-PCR. Data were analyzed by REST 2009 and SPSS. Results: Gene expression results showed up-regulation of P53 in 53 Breast cancersubjects and PTEN in 52 Breast cancer subjects compared with normal controls. However, there was lower P53 expression in 25 Breast cancer samples compared tonormal tissues. PTEN expression was lower in 26 Breast cancer samples than normaltissues. P53 showed a significant relationship to HER2 receptor (P=0. 024) andmenopausal status (P=0. 013); no significant relationships existed with other clinicopathologicalparameters (P>0. 05). PTEN had the only significant correlation withlymphatic invasion (P=0. 046) without any relation with other clinicopathologicalfeatures (P>0. 05). PTEN expression had no significant association with P53 expressionin the studied population (P=0. 074). Conclusion: Combined detection of PTEN and P53 may have the potential toestimate the pathobiological behavior and prognosis of Breast cancer. Due to theheterogeneous nature of cancer and the presence of different factors involved in theclinical situation of Breast cancer, we suggest a study of a larger population and morebiomarkers.

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    • Cite

    APA: Copy

    Salmani, Hamzeh, HOSSEINI, ARSHAD, AZARNEZHAD, ASAAD, & Ahmad, Hussain. (2018). PTEN and p53 Gene Expressions inBreast Cancer Specimens and their Clinicopathological Significance. MIDDLE EAST JOURNAL OF CANCER, 9(2), 105-111. SID. https://sid.ir/paper/321226/en

    Vancouver: Copy

    Salmani Hamzeh, HOSSEINI ARSHAD, AZARNEZHAD ASAAD, Ahmad Hussain. PTEN and p53 Gene Expressions inBreast Cancer Specimens and their Clinicopathological Significance. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(2):105-111. Available from: https://sid.ir/paper/321226/en

    IEEE: Copy

    Hamzeh Salmani, ARSHAD HOSSEINI, ASAAD AZARNEZHAD, and Hussain Ahmad, “PTEN and p53 Gene Expressions inBreast Cancer Specimens and their Clinicopathological Significance,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 2, pp. 105–111, 2018, [Online]. Available: https://sid.ir/paper/321226/en

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