The Relationship between MatrixMetalloproteinase Gene Polymorphismsand Tumor Type, Tumor Size, andMetastasis in Women with Breast Cancerin Central Iran

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Dehghan Manshadi Zahra; HAMID MOHAMMAD; KOSARI FARID; TAYEBINIA HEIDAR; KHODADADI IRAJ

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Journal: MIDDLE EAST JOURNAL OF CANCER Year:2018 | Volume:9 | Issue:2 Page(s): 123-131

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Title

The Relationship between MatrixMetalloproteinase Gene Polymorphismsand Tumor Type, Tumor Size, andMetastasis in Women with Breast Cancerin Central Iran

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Keywords

Breast neoplasms

Matrix metalloproteinases

Neoplasm metastasis

Singlenucleotide polymorphism

Abstract

Background: Matrix metalloproteinases-2 and-9 play important roles in thedevelopment of breast cancer by hydrolyzing the extracellular matrix. Since − 1306C/Tand − 1562C/T polymorphisms are located at the promoter regions of the matrix metalloproteinase-2 and-9 genes, respectively, C to T substitution may affect promoteractivity and impact the rate of extracellular matrix degradation and cancerous cellproliferation. Therefore, we aimed to determine the genotype and allele frequencies ofthese polymorphisms in Iranian healthy women and women with breast cancer. We havealso examined the correlation of genotypes with clinicopathological parameters suchas tumor type, tumor size, and metastasis to lymph nodes. Methods: This case-control study enrolled 200 women with breast cancer and 200age-matched healthy women. DNA was extracted, and we determined the genotypeand allele frequencies of − 1306C/T matrix metalloproteinase-2 and − 1562C/T matrixmetalloproteinase-9 polymorphisms by the polymerase chain reaction-restrictionfragment length polymorphism method. Additionally, tumor size (<20 mm/>20 mm), tumor type (ductal/non-ductal), and metastasis (yes/no) were determined. Results: Genotype and allele frequencies of the − 1306C/T matrix metalloproteinase-2 polymorphism showed no significant association with the occurrence ofbreast cancer. Genotype and allele distribution differed in the − 1562C/T matrix metalloproteinase-9 polymorphism and indicated a 4. 83-fold increase in the risk of breastcancer for T allele carriers. There was no likelihood of any interaction found betweenthe two polymorphisms and susceptibility to breast cancer. In addition, the − 1562C/Tmatrix metalloproteinase-9 T allele showed an association with metastasis to lymphnodes but we observed no association between the − 1306C/T matrix metalloproteinase-2 polymorphism and clinicopathological features. Conclusion: The ‒ 1562C/T matrix metalloproteinase-9 polymorphism is involvedin the pathogenesis of breast cancer in Iranian women. The T allele may increase therisk of disease.

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APA: Copy

Dehghan Manshadi, Zahra, HAMID, MOHAMMAD, KOSARI, FARID, TAYEBINIA, HEIDAR, & KHODADADI, IRAJ. (2018). The Relationship between MatrixMetalloproteinase Gene Polymorphismsand Tumor Type, Tumor Size, andMetastasis in Women with Breast Cancerin Central Iran. MIDDLE EAST JOURNAL OF CANCER, 9(2), 123-131. SID. https://sid.ir/paper/321229/en

Vancouver: Copy

Dehghan Manshadi Zahra, HAMID MOHAMMAD, KOSARI FARID, TAYEBINIA HEIDAR, KHODADADI IRAJ. The Relationship between MatrixMetalloproteinase Gene Polymorphismsand Tumor Type, Tumor Size, andMetastasis in Women with Breast Cancerin Central Iran. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(2):123-131. Available from: https://sid.ir/paper/321229/en

IEEE: Copy

Zahra Dehghan Manshadi, MOHAMMAD HAMID, FARID KOSARI, HEIDAR TAYEBINIA, and IRAJ KHODADADI, “The Relationship between MatrixMetalloproteinase Gene Polymorphismsand Tumor Type, Tumor Size, andMetastasis in Women with Breast Cancerin Central Iran,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 2, pp. 123–131, 2018, [Online]. Available: https://sid.ir/paper/321229/en

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