A Comparison of EndothelialCell-Selective Adhesion Molecule and vonWillebrand Factor Expression in BreastCancer Growth and Metastasis

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Cangara M. Husni; Hatta Mochammad; Miskad Upik A.; Wahid Syarifuddin

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Paper Information

Journal: MIDDLE EAST JOURNAL OF CANCER Year:2018 | Volume:9 | Issue:2 Page(s): 85-90

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Title

A Comparison of EndothelialCell-Selective Adhesion Molecule and vonWillebrand Factor Expression in BreastCancer Growth and Metastasis

Author(s)

Cangara M. Husni | Hatta Mochammad | Miskad Upik A. | Wahid Syarifuddin | Issue Writer Certificate

Keywords

Endothelial cell-selective adhesion molecule

von Willebrand factor

Breastcancer

Abstract

Background: Angiogenesis is the process of new blood vessels formation thatcontribute to tumor growth and metastasis. Endothelial cell-selective adhesion moleculeis one of the proteins that expresses in vascular endothelial cells. In vitro and animalstudies have shown involvement of this protein in physiological and pathologicalangiogenesis. von Willebrand factor is a protein expressed by endothelial cells andmegakaryocytes that has a role in blood clotting processes. In the current study, weinvestigate the expression of Endothelial cell-selective adhesion molecule and vonWillebrand factor in carcinoma mammae specimens and explore their correlationwith tumor growth and metastasis. Methods: We obtained 79 specimens from paraffin blocks of patients diagnosedwith invasive breast carcinoma of no special type. The slides from these specimens werethen stained with Endothelial cell-selective adhesion molecule, von Willebrand factor, and Ki-67 antibodies to assess vascular numbers and cell proliferation. Results: We found a total of 31 (39%) low vascularity and 48 (61%) high vascularitysamples from Endothelial cell-selective adhesion molecule staining. There were 34 (43%)low vascularity and 45 (54%) high vascularity samples by von Willebrand factorstaining. There was a significant correlation of blood vessel numbers in the endothelialcell-selective adhesion molecule-stained samples with tumor volume, metastasis to lymphnodes, and proliferation cells. The von Willebrand factor-expressed samples only hada significant correlation of vascular number with tumor volume. Conclusion: Endothelial cell-selective adhesion molecule and von Willebrandfactor as the endothelial cell expressed proteins play a role in the angiogenesis processof breast cancer. However, Endothelial cell-selective adhesion molecule expression ismore consistent than von Willebrand factor in predicting the presence or absence ofmetastatic breast cancer.

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APA: Copy

Cangara, M. Husni, Hatta, Mochammad, Miskad, Upik A., & Wahid, Syarifuddin. (2018). A Comparison of EndothelialCell-Selective Adhesion Molecule and vonWillebrand Factor Expression in BreastCancer Growth and Metastasis. MIDDLE EAST JOURNAL OF CANCER, 9(2), 85-90. SID. https://sid.ir/paper/321233/en

Vancouver: Copy

Cangara M. Husni, Hatta Mochammad, Miskad Upik A., Wahid Syarifuddin. A Comparison of EndothelialCell-Selective Adhesion Molecule and vonWillebrand Factor Expression in BreastCancer Growth and Metastasis. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(2):85-90. Available from: https://sid.ir/paper/321233/en

IEEE: Copy

M. Husni Cangara, Mochammad Hatta, Upik A. Miskad, and Syarifuddin Wahid, “A Comparison of EndothelialCell-Selective Adhesion Molecule and vonWillebrand Factor Expression in BreastCancer Growth and Metastasis,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 2, pp. 85–90, 2018, [Online]. Available: https://sid.ir/paper/321233/en

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